ArticleJornal brasileiro de nefrologia
The effects of pregnancy on the progression of maternal glomerular disease.
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Navigating Pregnancy With Primary Glomerular Disease: Experience From a Lower-Middle-Income Country.Kidney medicine · 2026Article
- Glomerular disease and pregnancy: contributions from a Brazilian cohort study.Jornal brasileiro de nefrologiaArticle
- Pregnancy and maternal glomerular disease: a closer look.Jornal brasileiro de nefrologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough most women with underlying glomerular diseases (GD) are of childbearing age, there is limited information on how pregnancy affects these conditions and maternal outcomes.
methodsWe carried out a single-center retrospective cohort study involving 44 planned pregnancies in 38 patients with biopsy-proven GD. Patients were divided into three groups based on their pre-conception CKD-KDIGO classification: I) Stage 1-2: 27 pregnancies, II) Stage 3a-3b: 11 pregnancies, and III) Stage 4-5: 6 pregnancies. Clinical data included age, chronic hypertension (CH), serum creatinine, preeclampsia (PE), and proteinuria. We considered CH, CKD stage before pregnancy, and PE and nephrotic proteinuria (NPu) during pregnancy as risk factors for maternal GD progression.
resultsWe found that 8 women progressed to ESRD and began hemodialysis during pregnancy: 2 (7.8%) in Group I, 1 (9.0%) in Group II, and 5 (83.3%) in Group III. In the remaining 36 pregnancies, we observed a significant GFR loss (p < 0.0001) one year after pregnancy, and GFR loss was greater in group II than in I (p < 0.013). Low GFR rates before pregnancy and PE during pregnancy (p = 0.001) directly impacted GFR loss. We also observed a high incidence (63.6%) of adverse fetal outcomes.
conclusionAlthough pregnancy is possible for women with GD, the impact of pregnancy in maternal GD continues after delivery. Having GD increases the risks of adverse pregnancy outcomes. The progression of GD is directly linked to the CKD stage before pregnancy and PE during pregnancy, and women in CKD stages 4-5 have a high risk of progressing to ESRD during gestation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.