ArticlePloS one2025
Neuroimaging insights into recent suicide attempters utilizing the raven task.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Melatonin: A Silver Bullet for Fertility and Reproductive Health.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding brain function in individuals who have recently attempted suicide is critical for improving diagnosis and treatment strategies. This study aimed to examine neural activity patterns in such individuals (who had attempted suicide 1-4 weeks before the study) using functional magnetic resonance imaging (fMRI) and the General Linear Model (GLM).
methodsSixty participants were recruited and categorized into three groups: individuals with a recent suicide attempt and Major Depressive Disorder (SA + MDD), individuals with Major Depressive Disorder without a suicide attempt (MDD), and healthy controls (HC). Participants performed the Raven task, consisting of 24 trials with a 25-second time limit for each item. Brain activity was analyzed to identify regional differences among groups using ANOVA, followed by Tukey's post-hoc pairwise comparisons.
resultsCompared to the MDD and HC groups, the SA + MDD group exhibited significantly reduced activation in the left medial superior frontal cortex (SFC), left anterior cingulate cortex (ACC), and left precentral gyrus. Positive correlations were observed between the Scale for Suicidal Ideation scores and activity in the medial SFC and ACC, whereas a negative correlation was found with precentral gyrus activity. While task accuracy did not significantly differ among the groups, the SA + MDD group demonstrated significantly shorter response durations.
conclusionIndividuals with recent suicide attempts show diminished activation in key left-hemispheric regions involved in cognitive control and problem-solving, including the medial SFC, ACC, and precentral gyrus. These neural deficits may impair decision-making and problem-solving abilities, particularly when compounded by hopelessness and a diminished sense of purpose, potentially contributing to increased suicide risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.