Evidence map›Paper›PMID 40758561›Full record

ArticleMicrobiology (Reading, England)2025

Engineering the TCA cycle regulator GarA to increase erythromycin production in

Anna D Liuzzi, Hannah L Tompkins, Sarah K Pallett, Lee Webster, Galina V Mukamolova, Matthew A Gregory, Martin Sim, Helen M O'Hare

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna D LiuzziDepartment of Respiratory Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.
Hannah L TompkinsDepartment of Respiratory Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.
Sarah K PallettDepartment of Respiratory Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.
Lee WebsterIsomerase Therapeutics, Newnham Building, Chesterford Research Park, Little Chesterford, Saffron Walden, Cambridge, Cambridgeshire, CB10 1XL, UK.
Galina V MukamolovaDepartment of Respiratory Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.
Matthew A GregoryIsomerase Therapeutics, Newnham Building, Chesterford Research Park, Little Chesterford, Saffron Walden, Cambridge, Cambridgeshire, CB10 1XL, UK.
Martin SimIsomerase Therapeutics, Newnham Building, Chesterford Research Park, Little Chesterford, Saffron Walden, Cambridge, Cambridgeshire, CB10 1XL, UK.
Helen M O'HareDepartment of Respiratory Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actinobacteria are important for industrial production of antibiotics, fine chemicals and food and a source of new compounds for drug discovery. Their central metabolism is regulated by a conserved protein GarA that is unique to the Actinobacteria and has been studied in

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCitric Acid CycleErythromycinMetabolic EngineeringSaccharopolysporaGene Expression Regulation, BacterialGlutamic AcidPhosphorylationAnti-Bacterial AgentsBacterial ProteinsErythromycinGlutamic Acidactinobacteriacentral metabolismerythromycinpolyketide biosynthesisprotein kinaseTCA cycle

Identifiers

PMID40758561
PMCPMC12321487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.