ArticleJournal of magnetic resonance imaging : JMRI2025
Comparison of Magnetic Resonance Spectra Acquired With Hybrid PET/MR and Standalone MR Scanners.
Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Comparison of Magnetic Resonance Spectra Acquired With Hybrid PET/MR and Standalone MR Scanners.Journal of magnetic resonance imaging : JMRI · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe effect of the positron emission tomography (PET) modality in hybrid PET/MR scanners on MR spectral quality is unclear. PURPOSE: To evaluate spectral quality, quantification, and repeatability of brain MR spectroscopy (MRS) acquired on PET/MR and standalone MR scanners. STUDY TYPE: Prospective. SUBJECTS: 23 healthy adults (male/female = 11/12, age = 27 ± 11 years). FIELD STRENGTH/SEQUENCE: 3T, semi-localized by adiabatic selective refocusing. ASSESSMENT: Single voxel MR spectra were acquired with GE Signa PET/MR and Siemens Prisma Fit MR scanners in healthy volunteers, and additionally with a GE Premier MR scanner in vitro. Spectral quality, metabolite concentrations, and repeatability were evaluated. STATISTICAL TESTS: Linear mixed models assessed signal-to-noise ratio (SNR), full width at half maximum (FWHM), and metabolites/total creatine (tCr). Intraclass correlation coefficients (ICCs) determined repeatability; mean squared error (MSE) evaluated accuracy of quantification. Values are reported as mean ± standard deviation. Significance was determined by p ≤ 0.05.
resultsIn vivo spectra acquired using the Siemens standalone MR showed significantly higher SNR (PET/MR: 118.8 ± 19.1, MR: 132.2 ± 24.4) but significantly broader FWHM (PET/MR: 7.2 ± 1.8 Hz, MR: 8.4 ± 2.5 Hz) compared to PET/MR. All metabolite ratios were significantly higher in spectra acquired on the standalone MR. Within-session repeatability was good (ICC > 0.75), and between-session repeatability was moderate to excellent (ICC 0.5 to > 0.90) for all metabolites in vivo. In vitro spectra acquired with the PET/MR had significantly higher SNR (329.1 ± 46.1) than the Siemens standalone MR (150.8 ± 49.3) but significantly lower than the GE standalone MR (395.9 ± 33.7). The PET/MR produced narrower FWHM (2.1 ± 0.4 Hz) than the Siemens standalone MR (4.1 ± 1.7 Hz) but broader than the GE standalone MR (1.6 ± 0.1 Hz) and lower MSE for some metabolites. DATA
conclusionMR spectral quality appears uncompromised when acquired with hybrid PET/MR compared to standalone MR.
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Registered trials
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