ArticleOrganic letters2025
Light-Mediated Binaphthyl Enhanced [2 + 2] Dearomatization of Heterocycles via an Energy-Transfer Process.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Visible-Light Mediated Activation of 1,3-Dienes and Allenes via Energy Transfers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
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Authors and funding
10 authors.
Funding
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Abstract
Three-dimensional heterocycles are crucial in medicinal chemistry, yet efficient methods for their preparation remain limited. We report a light-mediated [2 + 2] dearomatization strategy for simple and benzo-fused heteroaromatics via energy-transfer activation. A binaphthyl cocatalyst combined with an Ir-photocatalyst enables high yields and selectivity under mild conditions. Mechanistic studies reveal the fundamental role of the cocatalyst in stabilizing reactive intermediates via dispersion interactions. The versatility of the products was demonstrated through synthetic applications that smoothly increased the molecular complexity.
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Registered trials
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