ArticleInternational braz j urol : official journal of the Brazilian Society of Urology
Histological Analysis of the Prostate During the Human Fetal Period (12 to 22 Weeks Post-Conception).
Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to quantitatively analyze the stromal components of the prostate (collagen, muscle fibers and elastic system fibers) during prostate development in normal human fetuses, in order to establish normal growth patterns. MATERIALS AND
methodsTwenty-one normal human fetuses, aged between 12- and 22-weeks post-conception (WPC), were studied. The fetuses were divided into three groups: G1, n = 7, 12 to 16 WPC; G2, n = 6, 17 to 19 WPC, and G3, n = 8, 20 to 22 WPC. The samples were fixed in 4% buffered formalin and processed for paraffin embedding for histochemical analysis. Five 5-micrometer-thick sections were taken from each sample and stained using histochemical techniques to identify the prostate stromal components. Histomorphometric analyses were carried out by evaluating the area density of the parameters analyzed, in percentage, using ImageJ software.
resultsThe quantitative analysis of collagen fibers (p = 0.0616) and elastic system fibers (p = 0.6049) showed no significant difference between groups. Smooth muscle fibers were higher in G2 (+82.38%) and G3 (+108.81%) when compared to G1, p = 0.0020. Linear regression of the entire fetal period studied (12 to 22 WPC) showed a proportional increase in muscle fibers in relation to gestational age (r2 = 0.3398; p = 0.0056). Linear regression revealed a strong negative correlation between collagen fibers and smooth muscle fibers in G3 (20 to 22 WPC) (r2 = 0.8209; p = 0.0019).
conclusionsChanges in the stromal components of the prostate are more significant from the end of the second trimester of pregnancy. Collagen fibers and elastic system fibers showed stable growth throughout the fetal period studied. The density of smooth muscle fibers increased about twofold with increasing fetal age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.