ArticleBiochemical Society transactions2025
Anticancer drug development against ribosome synthesis and the nucleolus.
Article in Biochemical Society transactions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus.Molecular cell · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Nucleoli, the most prominent nuclear organelle, form around ribosomal DNA (rDNA) clusters at the p-arms of the five acrocentric chromosomes. Nucleoli are centers of ribosome synthesis, a vital activity in cell proliferation and organism viability. Ribosome biogenesis is a complex process involving the activity of all three RNA polymerases and numerous cellular factors. This energy-consuming process is, therefore, highly regulated, with the transcription of rDNA being the rate-limiting step. Given that uncontrolled cell proliferation is a hallmark of cancer, enhanced ribosome biogenesis plays a crucial role in sustaining tumor growth. In addition, nucleoli are multi-functional organelles, participating in genome organization, cell cycle, stress sensing, macromolecular trafficking, and the sequestration of cellular factors-functions that are also significantly altered in cancerous conditions. This review focuses on summarizing the role of nucleoli in carcinogenesis and anticancer therapeutics that target nucleoli and ribosome synthesis.
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Registered trials
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