ArticleEuropean journal of clinical pharmacology2025
Use of nomograms based on the one-compartment model in the estimation of area under the blood concentration-time curve of vancomycin: a retrospective cohort study.
Article in European journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent guidelines for vancomycin dosing and monitoring recommend calculating area under the concentration-time curve (AUC) using a Bayesian approach. However, Bayesian approaches are challenging, requiring specialised software and expertise. Thus, simpler AUC calculation methods are required.
aimTo develop and validate a nomogram to estimate the AUC of vancomycin based on the mathematical equation of the one-compartment model, and to investigate the clinical applicability of the apparent volume of distribution (Vd
methodsAUC values based on the nomogram and the Bayesian approach were compared in 51 patients who received vancomycin between May 2022 and December 2023. The first peak concentration and steady-state trough concentrations were measured in all patients, and Vd
resultsThe regression line relating the AUC based on the nomogram to the Bayesian approach had a slope of 0.988 (95% CI, 0.855, 1.131) and an intercept of 5.35 (95% CI, - 48.59, 64.26). Kendall's tau was 0.643 (P < 0.01), indicating a positive correlation.
conclusionThe estimation method utilising AUC nomograms and Vd
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.