ArticleCornea2025
Adjunctive Topical Calcineurin Inhibitors During the Treatment of Fungal Keratitis: Practice Patterns and Opinions.
Article in Cornea, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Emerging treatments in fungal keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Anti-inflammatory treatments in microbial keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeSuccessful antifungal treatment for fungal keratitis does not always result in a good visual outcome. Both infectious and inflammatory components of the disease result in visually significant corneal opacification. We conducted a survey of cornea specialists to elicit expert opinion on the role topical calcineurin inhibitors may play in the management of fungal keratitis.
methodsAn online survey was sent to subscribers of several cornea-focused listservs. Descriptive statistics were performed.
resultsOne hundred thirty-five participants completed the online survey. Approximately 48% of respondents practiced medicine in the United States and 36% in India. About 23% presently "sometimes" prescribe topical calcineurin inhibitors. And 70% never prescribe. When administered adjunctively to topical antifungal drops, 59% of respondents predict 1% to 2% topical cyclosporin would have a clinically significant antiinflammatory effect compared with 33% for the 0.05% to 0.1% cyclosporin dose. About 50% believe the 0.1% tacrolimus dose would have a clinically significant antiinflammatory activity compared with the 0.03% tacrolimus dose. Overall, those surveyed predicted adjunctive topical calcineurin inhibitors could improve final visual acuity by almost one line of vision.
conclusionsVaried opinions exist regarding the role adjunctive topical calcineurin inhibitors can play during a treatment course of fungal keratitis. The overall impression is that these agents may help clinical outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.