Evidence map›Paper›PMID 40757857›Full record

ArticleJournal of virology2025

Modeling of hepatitis B virus infection spread in primary human hepatocytes.

Zhenzhen Shi, Masataka Tsuge, Nicholson Collier, Yasue Takeuchi, Takuro Uchida, Carolyn M Rutter, Yuji Teraoka, Susan L Uprichard, Yuji Ishida, Chise Tateno and 3 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Zhenzhen ShiThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Masataka TsugeThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.ORCID 0000-0001-7591-8287
Nicholson CollierConsortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.
Yasue TakeuchiHepatitis Information Center, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan.
Takuro UchidaDivision of Travel Medicine and Health, Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Yufu, Japan.
Carolyn M RutterFred Hutchinson Cancer Research Center, Hutchinson Institute for Cancer Outcomes Research, Biostatistics Program, Public Health Sciences Division, Seattle, Washington, USA.
Yuji TeraokaGastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Susan L UprichardThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.ORCID 0000-0001-5691-1557
Yuji IshidaPhoenixBio Co., Ltd., Higashi-Hiroshima, Japan.
Chise TatenoPhoenixBio Co., Ltd., Higashi-Hiroshima, Japan.
Jonathan OzikConsortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.
Harel DahariThe Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.ORCID 0000-0002-3357-1817
Kazuaki ChayamaHiroshima Institute of Life Sciences, Hiroshima, Japan.

Funding

Data-Driven Mathematical and Computational Modeling of Hepatitis D Infection and Treatment ResponseR01AI146917 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI DAHARI, HAREL · 2020 to 2024
$3.5M
Collaborative Integration of Hepatitis B Molecular Virology and Mathematical/Computational ModelingR01AI144112 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI DAHARI, HAREL, UPRICHARD, SUSAN L. · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI144112NIAID NIH HHS R01 AI146917
6 · The paper itself

Abstract

Chronic hepatitis B virus (HBV) infection poses a significant global health threat, causing severe liver diseases including cirrhosis and hepatocellular carcinoma. We characterized HBV DNA kinetics in primary human hepatocytes (PHHs) over 32 days post-inoculation (p.i.) and modified our

Indexed as

Hepatitis BHepatitis B, ChronicHepatitis B virusHepatocytesAnimalsCells, CulturedDNA, ViralHumansKineticsModels, BiologicalVirus InternalizationVirus ReplicationDNA, Viralagent-based modelinghepatitis B virusMyr-preS1 treatmentprimary human hepatocytesviral hepatitis

Identifiers

PMID40757857
PMCPMC12455953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.