SynthesisUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2025
Impact of endometrial thickness on reproductive outcome in fresh and frozen-thawed embryo transfer: systematic review and meta-analysis.
Synthesis in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acupuncture as an adjunctive therapy on embryo transfer day: a systematic review and meta-analysis of clinical pregnancy and live birth outcomes.Frontiers in reproductive health · 2025Pooled it
- Development and Internal Evaluation of an Integrated Patient-Embryo-Endometrial Scoring System for Predicting Biochemical Pregnancy in IVF: A Proof-of-Concept Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- A Retrospective Analysis of Pregnancy Outcomes Following Frozen Embryo Transfer in Patients With Persistent Chronic Endometritis: A Five-Year Single-Center Study.Immunity, inflammation and disease · 2026Article
- Effect of basal LH levels on pregnancy outcome after IVF/ICSI fresh embryo transfer in patients of different ages: a retrospective study.Frontiers in endocrinology · 2026Article
- A case series: thirty-three cases with heterotopic pregnancy after assisted reproductive technology.Frontiers in medicine · 2026Article
- Development and external validation of a three-stage model to predict live birth after fresh IVF/ICSI embryo transfer.Frontiers in endocrinology · 2026Article
- The impact of the interaction between ovarian markers and the endometrium on the outcomes of assisted reproduction.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the impact of endometrial thickness on the reproductive outcomes of embryo transfer (ET) treatments using both cut-off-based meta-analysis and meta-analysis of proportions.
methodsThis was a systematic review and meta-analysis of comparative studies (randomized controlled trials, cohort studies, case-control studies) and descriptive studies (cross-sectional studies, case series) published in English, French, German, Italian or Spanish and analyzing the impact of endometrial thickness on the rates of embryo implantation, clinical pregnancy, live birth, miscarriage and/or ectopic pregnancy in fresh and/or frozen-thawed ET cycles. Live-birth rate was defined as the primary outcome. The literature search was conducted in MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Web of Science and ÍnDICEs-CSIC, from inception of each database until 1 September 2024. The risk of bias was assessed using the Newcastle-Ottawa scale for analytical studies and the Joanna Briggs Institute tool for descriptive studies. Pooled effects were estimated as odds ratios (OR) or risk differences obtained from a random-effects model, with 95% CIs. Linear meta-regression was used to assess the relationship between risk difference and endometrial thickness cut-off. Meta-analysis of proportions was performed as a secondary analysis, comparing outcome rates between 2-mm intervals of endometrial thickness and a reference category (≥ 6 to < 8 mm).
resultsA total of 67 studies were included, of which 22 were cohort studies and 45 were descriptive. In fresh ET cycles, the live-birth rate was higher in patients with a thicker endometrium across cut-offs from ≥ 5 mm (OR, 5.66 (95% CI, 1.10-28.98)) to ≥ 15 mm (OR, 1.49 (95% CI, 1.26-1.77)). Effect size decreased linearly as the cut-off increased (P < 0.0001; R
conclusionsEndometrial thickness is associated with reproductive outcomes, but demonstrates a gradient of effectiveness as a prognostic indicator, rather than offering a critical threshold below which ET should be avoided. ET scheduling should consider endometrial thickness alongside other prognostic factors. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
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