ArticleThe journal of spinal cord medicine2026
Quality of life in children with myelomeningocele undergoing intrauterine repair and postnatal surgery.
Article in The journal of spinal cord medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
contextMyelomeningocele (MMC) is the most common congenital neural tube defect, affecting multiple organs and significantly impacting survival and quality of life. Intrauterine MMC repair reduces the need for ventricular shunting and increases independent ambulation rates.
objectiveTo evaluate the quality of life in children with MMC who underwent intrauterine versus postpartum repair.
designA cross-sectional study utilized the PedsQL questionnaire, administered to guardians of children aged 2-7 years.
settingSarah Hospital-Rio de Janeiro.
participantsThis study included 28 children who underwent intrauterine myelomeningocele repair and 65 who underwent postpartum repair. OUTCOME MEASURES: The statistical tests were logistic regression and Pearson correlation coefficient.
resultsThe intrauterine group showed greater ambulation likelihood (P=0.007) and a functional level mainly in lumbar and sacral regions, compared to thoracic and lumbar functional levels in the the postpartum group (P=0.004). Hydrocephalus was present in 89.3% (25) of the intrauterine group and 100% (65) of those in the postnatal group (P=0.025). Ventriculoperitoneal (VP) shunting was required in 49.2% (12) of the intrauterine group and 60.0% (52) in the postpartum group (P=0.001). Clean intermittent catheterization was performed in 82.2% (25) of children with intrauterine repair and 81.5% (53) of those with postpartum repair (P=0.945). Prematurity was higher in the intrauterine group (OR 10.25; 95% CI 3.17-33.10). Guardians reported better quality of life in physical (P=0.035), social (P=0.035), psychosocial domains (P=0.019), and total score (P=0.016) for the intrauterine group.
conclusionIntrauterine repair was associated with better health-related quality of life outcomes.
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