Evidence map›Paper›PMID 40757652›Full record

ArticleThe Journal of physiology2025

5-HT

Tzu-Yi Lee, Yu-Hsuan Lin, Wen-Ying Chang, Li-Yu Lin, Che-Feng Chang, Wei-Ting Kuo, Chia-Hung Tu, Ming-Shiang Wu, Ling-Wei Hsin, Linda Chia-Hui Yu

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Emergence of invasiveGut microbes · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tzu-Yi LeeGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Yu-Hsuan LinGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Wen-Ying ChangGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Li-Yu LinGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Che-Feng ChangGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Wei-Ting KuoDepartment of Oral Biology, National Taiwan University College of Medicine, Taipei, Taiwan.ORCID 0000-0002-1230-0014
Chia-Hung TuDepartment of Internal Medicine, National Taiwan University Hospital.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital.
Ling-Wei HsinSchool of Pharmacy, National Taiwan University, Taipei, Taiwan.ORCID 0000-0001-5018-4491
Linda Chia-Hui YuGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.ORCID 0000-0003-1461-3249

Funding

National Science and Technology Council MOST 110-2320-B-002-011-MY3National Science and Technology Council MOST 110-2622-B-002-013National Science and Technology Council NSTC 111-2622-B-002-016National Science and Technology Council NSTC 113-2320-B002-062-MY3National Science and Technology Council NSTC 113-2823-8-002-002National Taiwan University 114L910203National Taiwan University NSCCMOH-216-81National Taiwan University NTU-114L890902National Taiwan University NTU-CC-112L895002National Taiwan University NTU-CC-113L892702
6 · The paper itself

Abstract

Dysregulated serotonin/5-hydroxytryptamine (5-HT) metabolism and dense mucosal neurite distribution are associated with visceral hypersensitivity (VH), which plays a key role in irritable bowel syndrome (IBS) pain symptoms. The 5-HT receptor subtype 7 (5-HT

Indexed as

AnalgesicsIrritable Bowel SyndromeNerve Growth FactorsReceptors, SerotoninSerotonin AntagonistsAnimalsBrain-Derived Neurotrophic FactorColitisColonDisease Models, AnimalHumansIntestinal MucosaMaleMiceMice, Inbred C57BLNerve Growth FactorAnalgesicsBrain-Derived Neurotrophic FactorNerve Growth FactorNerve Growth FactorsReceptors, Serotoninserotonin 7 receptorSerotonin Antagonistscolon hyperalgesiaenteric nervous systemirritable bowel syndromeneuroendocrinenociceptive afferentprimary neuron culturesserotonergic nervesubmucosal plexus

Identifiers

PMID40757652
PMCPMC12400787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.