ArticleVeterinary dermatology2025
Hydrocortisone Aceponate for Chronic Otitis: Long-Term Efficacy.
Article in Veterinary dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Associations Between Otic Cytological Findings and Clinical Severity by Pathogen Group in Canine Otitis Externa: A Retrospective Study of 318 Cases.Veterinary dermatology · 2026Article
- Some of the Newest Therapeutic Methods in Canine Atopic Dermatitis.Veterinary sciences · 2026Review
- Treatment of canine otitis externa: a randomized, double-blinded, clinical field study comparing the hydrocortisone aceponate monotherapy to a multi-agent reference product.Frontiers in veterinary science · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffective management of otitis externa (OE) requires addressing all contributing factors to prevent chronicity and recurrence. Evidence on the long-term efficacy of topical corticosteroids in preventing recurrence and secondary infections remains limited.
objectivesThis retrospective noncontrolled study evaluated the efficacy of hydrocortisone aceponate (HCA) in resolving non-infectious chronic or recurrent (CR)-OE with or without proliferative changes, and preventing recurrence of acute episodes and secondary infections. ANIMALS: A total of 63 owned dogs (115 ears) with unilateral or bilateral non-infectious CR-OE were included. Most ears were enrolled after resolving infectious otitis, as persistent inflammation or recurrence required further management. MATERIALS AND
methodsClinical records from two dermatology referral centres (February 2022-July 2023) were reviewed. Dogs were included if they had recurrent otitis for over a year (≥ 1 year) or chronic otitis (≥ 1 month). Otitis severity was assessed using the Otitis Index Score (OTIS3) scale, and by grading stenosis and hyperplasia severity. Enrolled patients received HCA 0.584 mg/mL at weight-adjusted doses. A reactive phase continued until OTIS3 < 2, followed by a proactive phase with regimens adapted to otitis severity. Concurrent treatments were recorded.
resultsRecurrence was not observed in 79.1% of ears (mean follow-up 202.6 days). Among 24 relapsed ears, 29.17% recurred after treatment discontinuation. Higher recurrence was associated with stopping therapy (p < 0.001) and recent bacterial otitis (p = 0.015). No adverse effects were noted. CONCLUSIONS AND CLINICAL RELEVANCE: The use of HCA appears to be an effective and safe option for reactive and proactive management of non-infectious CRC-OE, reducing recurrences and improving patient and owner quality-of-life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.