Evidence map›Paper›PMID 40757442›Full record

ArticleNano letters2025

Programmable RNA Nanostructures Enable Nanopore Detection of Cotranscriptionally Introduced RNA Modifications.

Iva Mohora, Gerardo Patiño Guillén, Kevin Neis, Julián Valero, Ulrich F Keyser, Filip Bošković

Abstract read
In one paragraph

Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iva MohoraCavendish Laboratory, University of Cambridge, 19 JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.ORCID 0009-0008-6813-6955
Gerardo Patiño GuillénCavendish Laboratory, University of Cambridge, 19 JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
Kevin NeisInterdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus, Denmark.
Julián ValeroInterdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus, Denmark.
Ulrich F KeyserCavendish Laboratory, University of Cambridge, 19 JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
Filip BoškovićCavendish Laboratory, University of Cambridge, 19 JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.ORCID 0000-0001-7663-2408

Funding

EPSRC CDT MRes/PhD Studentship in Nanoscience and NanotechnologyEuropean UnionNovo Nordisk Foundation to the Center for Multifunction Biomolecular Drug DesignTrinity-Henry Barlow Scholarship.
6 · The paper itself

Abstract

Tracking RNA synthesis and metabolic histories requires cotranscriptional incorporation of modified nucleotides. However, identifying the incorporation of modified nucleotides into nascent RNA remains challenging, particularly for short RNAs. In this work, we developed a method utilizing solid-state nanopores and DNA:RNA nanostructures to detect modified nucleotide incorporation across different RNA length scales, from short to long RNAs transcribed

Indexed as

NanoporesNanostructuresRNAAzidesBiotinClick ChemistryDNAUridineAzidesBiotinDNARNAUridineDNA and RNA nanotechnologymodified nucleotidesnanopore sensingRNA labelingsolid-state nanopores

Identifiers

PMID40757442
PMCPMC12356122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.