Evidence map›Paper›PMID 40757274›Full record

ArticleACS omega2025

Cerebrospinal Fluid p‑Tau181/Amyloid Beta 42 Ratio Identifies Lymphatic-Venous Anastomosis Patients Who Respond to and Benefit from the Surgery for Relief of Cognitive Impairment with a Diagnostic Accuracy of 0.744.

Guangqi Xu, Qinghua Zhang, Yinan Li, Anqi Du, Xiaona Xu, Ruyu Bai, Chao Bi, Yanxia Li, Tailun Zhang, Zhongfa Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guangqi XuDepartment of Reconstructive Surgery and Wound Repair, Shandong Public Health Clinical Center Affiliated to Shandong University, Panlongshan Campus, 2999 Guangxing West Road, Jinan, Shandong 655442, China.
Qinghua ZhangDepartment of Neurology, Shandong Public Health Clinical Center Affiliated to Shandong University, Panlongshan Campus, 2999 Guangxing West Road, Jinan, Shandong 655442, China.
Yinan LiCenter for Mass Spectrometry Research and Clinical Application, and Center for Integrative and Translational Medicine, Shandong Public Health Clinical Center Affiliated to Shandong University, Lishan Campus, 46 Lishan Road, Jinan, Shandong 250013, China.
Anqi DuCenter for Mass Spectrometry Research and Clinical Application, and Center for Integrative and Translational Medicine, Shandong Public Health Clinical Center Affiliated to Shandong University, Lishan Campus, 46 Lishan Road, Jinan, Shandong 250013, China.
Xiaona XuCenter for Mass Spectrometry Research and Clinical Application, and Center for Integrative and Translational Medicine, Shandong Public Health Clinical Center Affiliated to Shandong University, Lishan Campus, 46 Lishan Road, Jinan, Shandong 250013, China.
Ruyu BaiCenter for Mass Spectrometry Research and Clinical Application, and Center for Integrative and Translational Medicine, Shandong Public Health Clinical Center Affiliated to Shandong University, Lishan Campus, 46 Lishan Road, Jinan, Shandong 250013, China.
Chao BiDepartment of Reconstructive Surgery and Wound Repair, Shandong Public Health Clinical Center Affiliated to Shandong University, Panlongshan Campus, 2999 Guangxing West Road, Jinan, Shandong 655442, China.
Yanxia LiDepartment of Neurology, Shandong Public Health Clinical Center Affiliated to Shandong University, Panlongshan Campus, 2999 Guangxing West Road, Jinan, Shandong 655442, China.
Tailun ZhangSchool of Foreign Languages and Literature, Shandong University, 5 Hongjialou Road, Jinan, Shandong 250100, China.
Zhongfa ZhangDepartment of Reconstructive Surgery and Wound Repair, Shandong Public Health Clinical Center Affiliated to Shandong University, Panlongshan Campus, 2999 Guangxing West Road, Jinan, Shandong 655442, China.
Ivan K ChuCenter for Mass Spectrometry Research and Clinical Application, and Center for Integrative and Translational Medicine, Shandong Public Health Clinical Center Affiliated to Shandong University, Lishan Campus, 46 Lishan Road, Jinan, Shandong 250013, China.ORCID https://orcid.org/0000-0003-0652-975X
K W Michael SiuCenter for Mass Spectrometry Research and Clinical Application, and Center for Integrative and Translational Medicine, Shandong Public Health Clinical Center Affiliated to Shandong University, Lishan Campus, 46 Lishan Road, Jinan, Shandong 250013, China.ORCID https://orcid.org/0000-0002-9551-6506
Zhaoyan YuCenter for Mass Spectrometry Research and Clinical Application, and Center for Integrative and Translational Medicine, Shandong Public Health Clinical Center Affiliated to Shandong University, Lishan Campus, 46 Lishan Road, Jinan, Shandong 250013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Responders (R) and Non-Responders (NR) to lymphatic-venous anastomosis (LVA) surgery for relief of cognitive impairment show significant difference in their p-tau181/Aβ42 ratios via enzyme-linked immunosorbent assay (ELISA) of their cerebrospinal fluid (CSF). LVA involves the conjugation of a lymph vessel to a small vein in the neck to facilitate lymph flow. The R and NR groups were classified using five standard cognitive assessment tools: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Alzheimer's Disease Assessment Scale - Cognitive subscale (ADAS-Cog), Activities of Daily Living (ADL) and Clinical Dementia Rating (CDR), and augmented by clinical assessments. ELISA results for 43 patients were available. Welch's

Identifiers

PMID40757274
PMCPMC12311703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.