Evidence map›Paper›PMID 40757175›Full record

ArticleNPJ dementia2025

High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer's Disease Study.

Yara Alkhodair, Ging-Yuek R Hsiung, Boon Lead Tee, Pei-Chuan Ho, Phoenix Au Yeung, Wai Haung Yu, Guerry Peavy, Victor W Henderson, Yun-Beom Choi, Clara Li and 5 more

Abstract read
In one paragraph

Article in NPJ dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yara AlkhodairDivision of Neurology, University of British Columbia, S151 - 2211 Wesbrook Mall, UBC Hospital, Vancouver, BC V6T 2B5 Canada.
Ging-Yuek R HsiungDivision of Neurology, University of British Columbia, S151 - 2211 Wesbrook Mall, UBC Hospital, Vancouver, BC V6T 2B5 Canada.
Boon Lead TeeMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4th St Suite 212, San Francisco, CA 94158 USA.
Pei-Chuan HoPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, 3700 Hamilton Walk, Richards Building D101, Philadelphia, PA 19104 USA.
Phoenix Au YeungDivision of Neurology, University of British Columbia, S151 - 2211 Wesbrook Mall, UBC Hospital, Vancouver, BC V6T 2B5 Canada.
Wai Haung YuDepartment of Pharmacology and Toxicology, University of Toronto, Medical Sciences Building, King's College Cir Room 4207, Toronto, ON M5S 1A8 Canada.
Guerry PeavyDepartment of Neurosciences, University of California at San Diego, 9500 Gilman Dr, La Jolla, CA 92093 USA.
Victor W HendersonDepartment of Epidemiology and Population Health, Stanford University, 291 Campus Drive, Li Ka Shing Building, Stanford, CA 94305 USA.
Yun-Beom ChoiEnglewood Health, 350 Engle Street, Englewood, NJ 07631 USA.
Clara LiAlzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029 USA.
Dolly Reyes-DumeyerGertrude H. Sergievsky Center, Taub Institute of Aging Brain and Department of Neurology at Columbia University, 630 West 168th Street, New York, NY 10032 USA.
Haeok LeeRory Meyers College of Nursing, New York University, 433 1st Ave, New York, NY 10010 USA.
Walter A KukullDepartment of Epidemiology, University of Washington, 3980 15th Ave NE, Seattle, WA 98195 USA.
Clinical Core of the Asian Cohort for Alzheimer’s Disease (ACAD)
Asian Cohort for Alzheimer’s Disease Study

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Thor Stein · 2020 to 2026
$42.4M
Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI HELENA Chang CHUI, Gyungah Jun · 2023 to 2026
$39.4M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOWARD J ROSEN · 2019 to 2026
$36.9M
Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0R01AG083926 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joshua Grill, Van My Ta Park · 2023 to 2026
$12.9M
Chinese American Eye StudyU10EY017337 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VARMA, ROHIT · 2009 to 2013
$10.2M
Chinese language versions of the National Alzheimer's Coordinating Center's Uniform Data Set version 4: a linguistic and cultural adaptation studyR01AG083840 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Clara Li, Boon Lead Tee · 2023 to 2026
$5.3M
Asian Cohort for Alzheimer's Disease (ACAD)R56AG069130 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHUI, HELENA CHANG, JUN, GYUNGAH · 2020 to 2021
$4.9M
COVID-19 Effects on the Mental and Physical Health of AAPI Survey Study (COMPASS) IIR24AG063718 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PARK, VAN MY TA · 2019 to 2021
$4.4M
The impact of bilingualism on cognitive reserve/resilience using socio-demographically and linguistically diverse populationsR01AG080469 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Suvarna Alladi, Ganesh M Babulal · 2023 to 2026
$4.0M
Research Infrastructure for the study of Alzheimer's Disease and Alzheimer's Disease-related dementias in older Asian AmericansUH2AG083258 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DONGMING, LI, CLARA · 2023 to 2024
$1.2M
A Pilot of Memory Support System for Older Chinese Americans with Mild Cognitive ImpairmentR61AG083582 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LI, CLARA · 2023 to 2024
$1.1M
NEI NIH HHS U10 EY017337NIA NIH HHS K23 AG062750NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG080469NIA NIH HHS R01 AG083840NIA NIH HHS R01 AG083926NIA NIH HHS R21 AG068757NIA NIH HHS R21 AG077649NIA NIH HHS R24 AG063718NIA NIH HHS R56 AG069130NIA NIH HHS R61 AG083582NIA NIH HHS U19 AG068753NIA NIH HHS U19 AG079774NIA NIH HHS U24 AG021886NIA NIH HHS UH2 AG083258
6 · The paper itself

Abstract

The Asian Cohort for Alzheimer's Disease (ACAD) study is a collaborative investigation of genetic and non-genetic risk factors for AD among Asian Americans and Canadians. Harmonization of diagnostic procedures across recruiting sites will be key to the dataset's efficacy. Forty-two participants who completed the consensus process across seven ACAD recruiting sites were re-reviewed by two further impartial raters. Cohen's Kappa coefficient was used to evaluate inter-rater agreement. The findings reveal the highest level of observed agreement at 88% and a Cohen's Kappa of 0.835, among site consensus participants and two levels of external review, affirming the reliability of our protocol. ACAD has developed a data collection and diagnostic process that allows consistency among sites that serve Asians speaking Korean, Chinese, and Vietnamese languages.

Indexed as

Alzheimer's diseaseDementia

Identifiers

PMID40757175
PMCPMC12310511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.