ReviewRSC advances2025
Revolutionizing rheumatoid arthritis therapy: the potential of lipid nanocarriers.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Design and development of piperine-loaded polymeric micellar gel for the management of rheumatoid arthritis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Theranostic Nanoprobes for Rheumatoid Arthritis: From Inflammation Visualization to Guided Precision Therapy.International journal of nanomedicine · 2026Review
- Advancing Arthritis Therapy: The Frontier of Targeted and Responsive Nanomedicine.International journal of nanomedicine · 2026Review
- Bridging Pharmacology and Nanotechnology: Mechanistic Insights into Traditional Chinese Medicine-Based Nanodelivery Systems for Rheumatoid Arthritis.International journal of nanomedicine · 2026Review
- Nanotechnology-driven synergy in cardio-oncology: enhancing tumor suppression and reducing cardiotoxicity.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovitis, systemic inflammation and autoantibodies, leading to joint damage and disability. RA pathogenesis is characterized by a dysregulated interaction between immune cells, particularly B cells and T cells, which release inflammatory cytokines. This review explores the pivotal role of these immune cells in sustaining the inflammatory response and contributing to tissue injury. We provide a comprehensive overview of current RA therapies, highlighting the limitations of conventional treatments and the pressing need for targeted drug delivery systems such as lipid nanocarrier-based therapies, including nano-emulsions, solid lipid nanoparticles (SLNs), niosomes, liposomes, transferosomes, and ethosomes. Emphasizing niosomes, we discuss their capacity to encapsulate multiple drugs, significantly enhancing bioavailability and therapeutic efficacy. By directing drug-loaded niosomes to inflamed synovial sites, this innovative approach minimizes systemic side effects while maximizing localized drug concentrations, thereby optimizing treatment outcomes for RA patients. This review underscores the importance of targeted (nano)drug delivery in improving patient's life quality and represents a significant step toward more effective, personalized RA therapies by deepening our understanding of the underlying mechanisms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.