ArticleJournal of reproduction & infertility
Time-Lapse Evaluation of Embryos in Non-Obstructive Azoospermia (NOA): High Rate of 1PN Fertilization and Rapid Embryo Development in TESE Compared to Ejaculated Sperm.
Article in Journal of reproduction & infertility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: Non-obstructive azoospermia (NOA), marked by impaired spermatogenesis, poses challenges in assisted reproduction. Limited data exist comparing chromosomal integrity of testicular versus ejaculated sperm. This study aimed to compare embryo morphokinetics, fertilization abnormalities, and PGT-A outcomes between embryos from ejaculated and testicular sperm in NOA cases. Methods: This retrospective study analyzed 397 patients from two IVF centers (2015-2023), with 317 using ejaculated sperm and 80 using testicular sperm from NOA patients. Fertilization patterns (2PN, 1PN, ≥3PN), embryo morphokinetics, and aneuploidy rates were assessed. Logistic regression examined factors influencing aneuploidy including male and female age, recurrent implantation failure (RIF), hormone levels, and oocyte quality, while chi-square and t-tests compared groups, with significance at p<0.05. Results: Embryos derived from testicular sperm developed faster than those from ejaculated sperm (p<0.05). The 2PN fertilization rate was significantly lower, while the 1PN rate was higher in the testicular sperm group (10.1% Conclusion: Our study identified advanced parental age and RIF as key predictors of embryo aneuploidy. PGT-A may improve outcomes, especially for older patients or those with RIF, regardless of sperm origin. Embryos from testicular sperm in NOA patients develop faster morphokinetically but show a higher rate of 1PN fertilization than those from ejaculated sperm.
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