ArticleFrontiers in neurology2025
fNIRS evidence of abnormal frontotemporal cortex activation and functional connectivity in depressed patients after stroke: neuromodulatory mechanisms from mild to moderate depression.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Person-Centered Approaches for Identifying Subgroups of Post-Stroke Depression: A Systematic Review of Observational Studies.Patient preference and adherence · 2026Review
- Machine Learning Based Identification of Depressive Symptoms Among Students in a Chinese University Using Functional Near-Infrared Spectroscopy.Alpha psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Post-stroke depression (PSD) is a prevalent psychiatric complication following a stroke, significantly delaying neurological recovery. The assessment of scales in clinical diagnosis often lacks objectivity, while functional near-infrared spectroscopy (fNIRS) has been recognized as an adjunctive diagnosis of depression. This research was designed to evaluate whether fNIRS signals can differentiate different degrees of PSD and explore the pathogenesis behind PSD. Methods: We recruited 56 stroke patients treated at the Wenzhou TCM Hospital of Zhejiang Chinese Medical University and stratified them into three groups according to PSD severity: non-PSD ( Results: In terms of brain activation, the moderate-PSD group demonstrated significantly diminished activation in four particular brain regions in comparison to the non-PSD group ( Conclusion: This study presents distinct patterns of frontotemporal cortex activation and functional connectivity alterations associated with varying severity levels of PSD. In contrast with patients with stroke alone, PSD patients showed decreased activation levels and abnormally increased functional connectivity, and this change was more pronounced in moderate-PSD patients. These findings indicate that functional features of the frontotemporal cortex may serve as a neural indicator for identifying high-risk cases of PSD. Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=249555, ChiCTR2400093089.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.