SynthesisFrontiers in pharmacology2025
Comparative effectiveness of traditional Chinese medicine injections combined with ACEI/ARB for diabetic nephropathy: A systematic review and network meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim of the study: This systematic review and network meta-analysis aimed to evaluate the comparative effectiveness of traditional Chinese medicine injections (TCMIs) combined with angiotensin-converting enzyme inhibitors or angiotensin Ⅱ receptor blockers for diabetic nephropathy (DN). Methods: Ten databases were searched. Primary endpoint indicators were urinary albumin excretion rate (UAER) and serum creatinine (Scr). Secondary endpoint indicators were blood urea nitrogen (BUN), urinary β Results: A total of 99 randomised controlled trials and ten TCMIs were included for analysis. Based on the surface under the cumulative ranking curve values, it was observed that the efficacy of the combination group was better than that of the control group. For the primary endpoints, the Shuxuetong and Shenkang injections were excellent in reducing UAER and Scr, respectively. The Danshen injection was the most effective for the total effective rate and BUN; the Shuxuetong, Yinxingdamo, Danshen-Chuanxiongqin, and Shuxuening injections were the most effective for total cholesterol, β Conclusion: In this study, it is indicated that when combined with ACEI/ARB, the Shuxuetong, Shenkang, Danshen, Danshen-Chuanxiongqin, Yinxingdamo, and Shuxuening injections may confer advantages in improving DN indicators. However, due to limitations in the methodological quality of the included studies (especially deficiencies in randomisation and blinding) and the critical lack of reporting on key information regarding TCMI components, the reliability of these findings is compromised.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.