ArticleJournal of maxillofacial and oral surgery2025
Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrın (i-PRF) Addition to Different Particle Sizes of Bovine Bone Grafts in Rabbit Calvaria Defects.
Article in Journal of maxillofacial and oral surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Bone grafts are indispensable in augmentation procedures, and their properties influence the new bone formation. It has proved that the injectable platelet-rich fibrin has many positive effects on bone healing. Aim: It was aimed to compare the effectiveness of the injectable platelet-rich fibrin (i-PRF) addition to bovine bone graft with different particle sizes on bone formation and vascularization in this study. Materials and Methods: In 18 New Zealand rabbits, critical sized defects were created in the calvarium. Bovine bone grafts of two different particle sizes, small particles (SP) (0.25-1.0 mm) and large particles (LP) (1.0-2.0 mm) were applied with injectable platelet-rich fibrin (i-PRF) and without i-PRF. Animals were killed at 4 and 10 weeks for examining early and late bone healing histomorphometrically and immunohistochemically. Results: Group SP + i-PRF had the significantly greater amount of new bone formation in both healing periods. The immunoreactivity scores of the vascular endothelial growth factor (VEGF) and osteocalcin (OCN) were found to be significantly higher in Group SP + i-PRF than the other groups. There has been detected significant relationship between i-PRF addition and OCN staining scores. Conclusion: In this study, which investigated the effectiveness of i-PRF in different particle sizes, it was concluded that i-PRF addition to small-particle bone graft increased new bone formation. There was no significant difference between two particle sizes of bone graft without i-PRF addition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.