Evidence map›Paper›PMID 40756896›Full record

ReviewCell stress2025

Sugar accelerates chronological aging in yeast via ceramides.

Vera Schmiedhofer, Julian Sommersguter-Wagner, Oskar Knittelfelder, Helmut Jungwirth, Gerald N Rechberger, Didac Carmona-Gutierrez, Patrick Rockenfeller, Christoph Ruckenstuhl, Frank Madeo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell stress, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vera SchmiedhoferInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Julian Sommersguter-WagnerInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Oskar KnittelfelderInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Helmut JungwirthCenter for society, knowledge and communication (7th faculty), University of Graz, Graz, Austria.
Gerald N RechbergerInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Didac Carmona-GutierrezInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Patrick RockenfellerChair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), University of Witten/Herdecke (UW/H), Witten, Germany.
Christoph RuckenstuhlInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.
Frank MadeoInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High carbohydrate intake, a characteristic of many Western diets, is a major contributor to age-associated pathologies. Here, we explored the molecular consequences of sugar overload during chronological aging in the yeast

Indexed as

agingcell stresschronological lifespanlipid homeostasislipotoxicitymetabolic syndromnutrient signalingTOR1VAC8

Identifiers

PMID40756896
PMCPMC12318584

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.