ArticleNeuro-oncology advances
Prediction of treatment failure and early identification of tumor progression after Gamma-Knife radiosurgery in vestibular schwannoma: A retrospective cohort study.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Microsurgical resection after failed radiosurgery (SRS) in vestibular schwannoma (VS) patients is associated with higher morbidity. Identifying factors that predict treatment failure (TF) is crucial. Additionally, distinguishing between pseudoprogression (PP) and true tumor progression (TP) can be challenging. This study aims to identify predictive factors for TF and investigate early features that differentiate PP from TP. Methods: A retrospective analysis was performed on 705 patients with unilateral sporadic VS who underwent SRS between 1998 and 2020. Clinical data, including patient characteristics, symptoms, tumor volume (TV), and onset of new symptoms after SRS, were recorded. The average follow-up was 4 years for the TP group ( Results: TF was more common in women ( Conclusions: Female sex and lower OHATA class were identified as independent predictors of TF. Hemifacial spasm occurrence after SRS was linked to TP. Failure of reduction of initial TV (RTV > 1) after 24 months was associated with TP with a high sensitivity and specificity, making PP unlikely.
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