Appropriateness of Antibiotic Prescriptions Written for Dental Prophylaxis Within a Regional Veterans Affairs Healthcare System Based on American Dental Association and American Academy of Orthopaedic Surgeons Guidance.

Background: We determined the prevalence of inappropriate dental prophylaxis antibiotic prescriptions written by providers within a Veterans Integrated Service Network based on American Dental Association (ADA) and American Academy of Orthopaedic Surgeons (AAOS) guidance. Methods: We conducted a retrospective cohort study of antibiotic prescriptions written for dental prophylaxis from 1 May 2023 through 30 April 2024. Prescriptions were defined as indicated if the patient met ADA guidance criteria. A subset of prescriptions written for patients with orthopedic implants was assessed for appropriateness when applying the 2017 and 2024 AAOS guidelines. Results: Of 622 prescriptions, 53%, 37%, and 10% were written due to underlying orthopedic, cardiac, and other conditions, respectively. Dentists prescribed 51% of prescriptions, followed by primary care providers (35%) and orthopedic specialists (9%). Overall, 67% prescriptions were not indicated. When considering indication, agent, and dose, 72% of prescriptions were inappropriate. Prescriptions written due to cardiac conditions were more likely to be indicated than prescriptions written due to orthopedic conditions ( Conclusions: Our results suggest substantial antibiotic overuse and lack of adherence with ADA and AAOS recommendations, particularly among patients with orthopedic implants. These results highlight the need for multifaceted stewardship interventions targeting not only dentists, but all types of providers.