Evidence map›Paper›PMID 40756653›Full record

ArticleOpen forum infectious diseases2025

Trends in Costs for HIV Care During a Hepatitis C Virus Early Treatment and Elimination Program: A Data Linkage Study of Claims and Swiss HIV Cohort Study Data.

Soheila Aghlmandi, Kurt Schmidlin, Carola Huber, Pascal Godet, Katharina Kusejko, Marcel Stoeckle, Matthias Cavassini, Huldrych F Günthard, Enos Bernasconi, Alexandra Calmy and 5 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Soheila AghlmandiDivision of Clinical Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-0180-3246
Kurt SchmidlinSwiss RDL Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-0486-4490
Carola HuberHelsana Versicherungen AG, Zurich, Switzerland.
Pascal GodetSanitas Krankenversicherung, Zurich, Switzerland.
Katharina KusejkoDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-4638-1940
Marcel StoeckleDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Basel, Basel, Switzerland.
Matthias CavassiniDivision of Infectious Diseases, University Hospital Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-0933-7833
Huldrych F GünthardDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-1142-6723
Enos BernasconiDivision of Infectious Diseases, Ente Ospedaliero Cantonale Lugano, University of Geneva and University of Southern Switzerland, Lugano, Switzerland.ORCID https://orcid.org/0000-0002-9724-8373
Alexandra CalmyHIV Unit, Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland.
Patrick SchmidDivision of Infectious Diseases, Infection Prevention and Travel Medicine, Cantonal Hospital St Gallen, St Gallen, Switzerland.ORCID https://orcid.org/0000-0003-1978-5082
Cornelia StaehelinDepartment of Infectious Diseases, Inselspital and University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-1733-7051
Niklaus D LabhardtDivision of Clinical Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-3599-1791
Heiner C BucherDivision of Clinical Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland.
Swiss HIV Cohort Study

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In Switzerland detailed individual patient data are lacking on trends in health care costs, major drivers of costs, and the contribution of breakthrough innovations, such as direct-acting agents (DAAs) for the treatment of chronic hepatitis C virus (HCV) infection in people with HIV (PWH). Methods: We linked anonymized data of patients undergoing antiretroviral therapy (ART) or naive patients initiating ART between 2012 and 2017 in the Swiss HIV Cohort Study with claims data of health insurers covering 35% of Swiss residents. Trends in mean annual costs for overall care, ART, and hospitalizations were calculated with an adjustment of costs for censoring. Changes in costs over time in relation to patient characteristics, comorbidities, and treatment of HCV with DAAs were estimated by linear mixed models. Costs were reported in Swiss francs (CHF). Results: The final linked file contained 1830 individuals from 11 286 participants of the Swiss HIV Cohort Study and 5406 claims records (33.9%). The mean adjusted annual overall cost in 2012 was CHF 24 713 (SD, 14 107) and increased in 2017 by 1.2% to CHF 24 881 (SD, 14 523). Costs for ART contributed by far most to overall costs but decreased over time. Mean costs for hospitalizations increased with annual variation by 7.2% from CHF 8727 (SD, 10 473) in 2012 to CHF 9406 (SD, 9696) in 2017. Mean increases of costs for DAAs for 171 PWH coinfected with HCV (9.4%) were CHF 52 647 (95% CI, 50 862-54 431; Conclusions: Increases in mean total costs for PWH in Switzerland from 2012 to 2017 were small. The contribution of DAAs for the treatment of chronic HCV to overall costs was marginal.

Indexed as

antiretroviral therapycostsdirect-acting agentshepatitis C infectionHIV infection

Identifiers

PMID40756653
PMCPMC12314359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.