ReviewFrontiers in cardiovascular medicine2025
Research status of triglyceride glucose-body mass index (TyG-BMI index).
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07589374 (Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived Metrics), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived Metrics
Who cites it
22 citing papers in PubMed.
- Association of the TyG-related indices with hypertension-diabetes comorbidity in middle-aged and older adults: a suburban community-based study.BMC cardiovascular disorders · 2026Article
- Mediation effect of TyG-BMI, LDL-C, and CRP on physical activity-stroke risk relationship.Scientific reports · 2026Article
- Association between the cumulative average triglyceride glucose-BMI and hypertension incidence among the middle-aged and older population: a prospective nationwide cohort study in China.Journal of hypertension · 2026Article
- Association Between Triglyceride Glucose Index and Postherpetic Neuralgia in Patients with Acute Herpes Zoster: A Retrospective Study.Pain and therapy · 2026Article
- Association of the Triglyceride-Glucose (TyG) Index and TyG-BMI With 1-Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion.CNS neuroscience & therapeutics · 2026Article
- Clinical Use of the Triglycerides/Glucose (TyG) Index in the Early Assessment of Metabolic Alterations and Cardiovascular Remodeling in Essential Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- The Predictive Value of TyG-BMI and TG/HDL-C for Metabolic Dysfunction-Associated Steatotic Liver Disease in Obstructive Sleep Apnea: A Single-Center Retrospective Cohort Analysis.Journal of clinical medicine · 2026Article
- Joint effects of triglyceride-glucose-BMI and stress hyperglycemia ratio on all-cause mortality in trauma surgical intensive care patients: a multicenter cohort study.Lipids in health and disease · 2026Article
- Association between the triglyceride-glucose index and hypertension: potential role of fatty liver in a cross-sectional study.Frontiers in endocrinology · 2026Article
- Correlation between TyG index, TyG-BMI index and AIP index and early-onset type 2 diabetic nephropathy.Frontiers in endocrinology · 2026Article
- Association between triglyceride glucose-body mass index and diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus: a retrospective cross-sectional study.Frontiers in medicine · 2026Article
- Glucose-lipid metabolic dysregulation and sleep fragmentation in obstructive sleep apnea: insights from a large-scale cross-sectional study and exploratory hypoxia-related single-nucleus transcriptomic analysis.Frontiers in nutrition · 2026Article
- Predictive value of insulin resistance related indicators for osteoporosis risk in patients with type 2 diabetes mellitus: a real-world study.Frontiers in molecular biosciences · 2026Article
- Article
- The joint association of insulin resistance index and neutrophil percentage to albumin ratio with acute kidney injury after orthopedic surgery: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Epicardial adipose tissue volume is associated with impaired left atrial mechanics in hypertensive overweight/obese patients: the potential mediating role of insulin resistance.Frontiers in nutrition · 2026Article
- The predictive value of surrogate insulin resistance indices for T2DM complicated with metabolic syndrome: a retrospective study based on hospitalized patients in China.Frontiers in endocrinology · 2026Article
- Association between triglyceride glucose-body mass index and nonunion in older patients following limb fracture surgery: a multicenter retrospective cohort study.Frontiers in medicine · 2026Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
- Understanding triglyceride glucose-body mass index: implications for diabetes and cardiovascular disease management.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance (IR) represents a pivotal metabolic risk factor, with metabolic abnormalities intricately linked to increased predisposition to cardiovascular, digestive, and immune system disorders. While the triglyceride glucose (TyG) index is widely recognized as a simple and specific surrogate marker for IR, the triglyceride glucose body mass index (TyG-BMI), incorporating obesity metrics, has emerged as a more robust predictor of IR. Growing evidence underscores the strong association between TyG-BMI index and multisystem diseases that span cardiovascular, metabolic, and neoplastic pathways. Monitoring TyG-BMI index enables proactive management of lifestyle modifications, dietary interventions, and physical health strategies, thereby reducing disease prevalence. This review synthesizes the pathophysiological mechanisms underlying TyG-BMI, alongside its clinical utility and cutting-edge research advancements in hypertension, coronary artery disease, stroke, diabetes, non-alcoholic fatty liver disease, hyperuricemia, and cancer. Particular emphasis is placed on the role of TyG-BMI index in influencing disease progression, highlighting its potential as a transformative biomarker for risk stratification and therapeutic targeting across diverse medical disciplines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.