ArticleFrontiers in endocrinology2025
Machine learning algorithm based on combined clinical indicators for the prediction of infertility and pregnancy loss.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Determining risk factors predicting miscarriage among couples undergoing assisted reproductive treatment: a systematic review.BMC pregnancy and childbirth · 2026Pooled it
- Development of machine learning models for predicting early pregnancy outcomes based on β-hCG, progesterone, and estradiol.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objectives: Diagnosis and treatment of infertility and pregnancy loss are complicated by various factors. We aimed to develop a simpler, more efficient system for diagnosing infertility and pregnancy loss. Methods: This study included 333 female patients with infertility and 319 female patients with pregnancy loss, as well as 327 healthy individuals for modeling; 1264 female patients with infertility and 1030 female patients with pregnancy loss, as well as 1059 healthy individuals for validating the models. The average age and basic information were matched between the groups. Three methods were used for screening 100+ clinical indicators, and five machine learning algorithms were used to develop and evaluate diagnostic models based on the most relevant indicators. Results: Multivariate analysis revealed significant differences in several factors between the patients and the control group. 25-hydroxy vitamin D3 (25OHVD3) was the factor exhibiting the most prominent difference, and most patients presented deficiency in the levels of this vitamin. 25OHVD3 is associated with blood lipids, hormones, thyroid function, human papillomavirus infection, hepatitis B infection, sedimentation rate, renal function, coagulation function, and amino acids in patients with infertility. The model for infertility diagnosis included eleven factors and exhibited area under the curve (AUC), sensitivity, and specificity values higher than 0.958, 86.52%, and 91.23%, respectively. The model for potential pregnancy loss was also developed using five machine learning algorithms and was based on 7 indicators. According to the results obtained from the testing set, the sensitivity was higher than 92.02%, the specificity was higher than 95.18%, the accuracy was higher than 94.34%, and the AUC was higher than 0.972. Conclusion: The simplicity, good diagnostic performance, and high sensitivity of the models presented here may facilitate early detection, treatment, and prevention of infertility and pregnancy loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.