Evidence map›Paper›PMID 40756472›Full record

ArticleInnovation in aging2025

Daily Movement Activities Are Associated With Within-Person Instability of Cognitive Function in Older Adults: Evidence From an Ambulatory Assessment Study.

Chih-Hsiang Yang, Donald Hedeker, Jongwon Lee, Halle Prine, Donna Coffman, Jingkai Wei, Jonathan George Hakun

Abstract read
In one paragraph

Article in Innovation in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Not just how much, but how it's done: movement activity bout distributions and everyday cognition in older adults with elevated dementia risk.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chih-Hsiang YangDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Donald HedekerDepartment of Public Health Sciences, Biological Sciences Division, The University of Chicago, Chicago, Illinois, USA.
Jongwon LeeDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Halle PrineDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Donna CoffmanDepartment of Psychology, College of Arts and Sciences, University of South Carolina, Columbia, South Carolina, USA.
Jingkai WeiDepartment of Family and Community Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jonathan George HakunDepartment of Neurology, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3389-7136

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Background and Objectives: Physical inactivity and excessive sedentary time (ST) are associated with poor cognitive health in older adults. However, current literature largely relies on cross-sectional designs or in-lab cognitive assessments, which do not adequately reflect cognitive function in naturalistic settings. Further, existing studies have largely overlooked the variability or the instability in daily cognitive function, which represents a critical marker of cognitive decline. This ambulatory assessment study examined the temporal associations of daily movement behaviors with the mean levels and the variability of cognition among older adults at risk of dementia. Research Design and Methods: 96 older adults from the community (68.3 ± 7.1 years) participated in this 14-day study. They wore an accelerometer and completed smartphone-based cognitive tests up to 4 times per day. The cognitive tests assessed both performance-based and subjective cognition. The movement behaviors collected from the accelerometers include daily light-intensity physical activity (LPA), moderate-to-vigorous physical activity (MVPA), and ST. Mixed-effects location-scale models were applied to estimate the within- and between-person associations of movement behaviors and cognitive outcomes in terms of the mean levels and the degree of variability. A total of 1,269 day-level observations were analyzed. Results: Older adults' between-person levels of daily MVPA and steps were associated with better mean cognitive performance and lower variability across cognitive measures. Older adults' daily LPA was positively associated with subjective cognition in both mean levels and variability. The increases in within-person levels of ST were negatively associated with older adults' variability of all cognitive outcomes. Discussion and Implications: Study results suggest that moving more and sitting less in day-to-day life may sustain proximal cognitive health. Applying ambulatory assessments can advance aging research by examining the temporal dynamics between daily movement activities and within-person variability of cognition to inform strategies for promoting healthy aging in daily life.

Indexed as

Cognitive agingIntraindividual variabilityLocation-scale modelingMovement-based behaviorsSedentary lifestyle

Identifiers

PMID40756472
PMCPMC12314498

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.