Evidence map›Paper›PMID 40756422›Full record

ArticleData in brief2025

Comprehensive characterization of human aqueous humor proteomes from primary open-angle glaucoma using data-independent acquisition dataset on a TimsTOF pro mass spectrometer.

Hu Xiao, Da Qian Lu, Jimmy Ka-Wai Cheung, Ying Hon Sze, Jing Fang Bian, Chi-Wai Do, Lei Zhou, Xiao Li Xing, Thomas Chuen Lam

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In one paragraph

Article in Data in brief, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hu XiaoThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, Guangdong, PR China.
Da Qian LuCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.
Jimmy Ka-Wai CheungCentre for Eye and Vision Research (CEVR), 17 W Hong Kong Science Park, Hong Kong.
Ying Hon SzeCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.
Jing Fang BianCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.
Chi-Wai DoCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.
Lei ZhouCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.
Xiao Li XingEye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Thomas Chuen LamThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, Guangdong, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary open-angle glaucoma (POAG) is the foremost cause of irreversible visual impairment, attributed to a complex array of ocular diseases. The lack of reliable prognostic indicators necessitates the development of biomarkers that can be used to detect and monitor glaucoma early in its course. In this study, human aqueous humor databases dedicated to advanced and not advanced POAG from Chinese were compiled to facilitate research on POAG, using advanced label-free quantitative proteomics technology by a TimsTOF Pro mass spectrometer. Proteins and peptides were identified and quantified by DIA-NN bioinformatics. All mass spectrometry data were deposited in the ProteomeXchange Consortium via the PRIDE partner (https://www.ebi.ac.uk/pride) with the dataset identifier PRIDE: PXD060484.

Indexed as

BiomarkersHuman aqueous humorMass spectrometryPrimary open angle glaucomaProteomic database

Identifiers

PMID40756422
PMCPMC12318253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.