Evidence map›Paper›PMID 40756349›Full record

ReviewTheranostics2025

Mesoporous nanomaterial-based smart nanoplatforms for precise therapies of ulcerative colitis: Strategies and challenges.

Zihong Xie, Jun Wu, Jin Xie, Hongxin Chen, Xinmin Wang, Junfeng Huang, Baode Shen, Hao Song, Lina Fu, Pengfei Yue

Abstract readReview
In one paragraph

Review in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zihong XieState Key Laboratory of Modern Preparation of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Jun WuDepartment of Pharmaceutics, 908th Hospital of Joint Logistics Support Force of PLA, Nanchang 330000, China.
Jin XiePharmacy Department, University of Kansas, Lawrence, KS 66045, USA.
Hongxin ChenState Key Laboratory of Modern Preparation of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Xinmin WangState Key Laboratory of Modern Preparation of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Junfeng HuangState Key Laboratory of Modern Preparation of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Baode ShenState Key Laboratory of Modern Preparation of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Hao SongAustralian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane QLD 4072, Australia.
Lina FuPharmacy Department, Shanghai Eighth People's Hospital, Shanghai, China.
Pengfei YueState Key Laboratory of Modern Preparation of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is a chronic inflammatory disease predominantly impacting the rectum and colon. Because UC has a complicated pathophysiology, there is no effective treatment so far. Over the past decade, nanomedicine has undergone a remarkable transformation and expansion in its application, driven by an increasingly profound comprehension of the multifaceted functions of diverse nanomaterials. Consequently, an increasing number of these advanced materials have been utilized in the treatment of UC. Notably, mesoporous nanomaterials (MNMs) have gained significant attention due to their unique physicochemical properties, including high specific surface area, tunable pore size, large pore volume, and customizable surface chemistry. These MNMs exhibit outstanding drug-loading capacity, controlled release behavior and excellent biocompatibility, which have been demonstrated successfully overcoming the limitations of conventional therapies. With increasing research interest and translational potential, this review highlights novel strategies for UC treatment by focusing on its physiopathological characteristics and summarizes recent advancements in applying MNMs for UC therapy. The design strategies of various MNM-based smart nanoplatforms as drug carriers for UC treatment are comprehensively reviewed, with critical challenges and future trends in the development and translation of MNMs for UC therapies also outlined. This review establishes a rational framework for designing smart drug delivery systems based on mesoporous nanomaterial and provides guidance and inspiration for UC and other inflammatory disease treatment.

Indexed as

Colitis, UlcerativeDrug CarriersNanostructuresAnimalsDrug Delivery SystemsHumansNanomedicinePorosityDrug Carriersdrug deliverymesoporous nanomaterialssmart nanotherapiesulcerative colitis

Identifiers

PMID40756349
PMCPMC12316103

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.