Evidence map›Paper›PMID 40756345›Full record

ArticleTheranostics2025

Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction.

Ajit Magadum, Vandana Mallaredy, Rajika Roy, Darukeshwara Joladarashi, Charan Thej, Zhongjian Cheng, Maria Cimini, May Truongcao, Adam Chatoff, Claudia V Crispim and 9 more

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ajit MagadumAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Vandana MallaredyAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Rajika RoyDepartment of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University School of Medicine, Durham, NC, USA.
Darukeshwara JoladarashiAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Charan ThejAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Zhongjian ChengAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Maria CiminiAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
May TruongcaoAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Adam ChatoffAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Claudia V CrispimAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Vagner O C RigaudCenter for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Carolina GonzalezAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Cindy BenedictAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Celio X C SantosKing's College London British Heart Foundation Centre, School of Cardiovascular Medicine & Sciences, United Kingdom.
Nathaniel W SnyderAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Mohsin KhanDepartment of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Ajay M ShahKing's College London British Heart Foundation Centre, School of Cardiovascular Medicine & Sciences, United Kingdom.
Walter J KochDepartment of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University School of Medicine, Durham, NC, USA.
Raj KishoreAging+Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Walter J. Koch · 2017 to 2026
$21.0M
Restoration of myocardial reparative function of diabetic progenitor cells by epigenetic modulationR01HL143892 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2020 to 2023
$2.2M
MyomiR-499, Exosomes and Endothelial and Endothelial Progenitor Cells dysfunction in DiabetesR01HL169405 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2024 to 2026
$1.8M
PSAT1 modified mRNA induces cardiac repair post-ischemic heart injuryR01HL169872 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Ajit Magadum · 2024 to 2026
$1.1M
NHLBI NIH HHS P01 HL134608NHLBI NIH HHS R01 HL143892NHLBI NIH HHS R01 HL169405NHLBI NIH HHS R01 HL169872
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Myocardial InfarctionSerineTransaminasesAdaptor Proteins, Signal TransducingAnimalsApoptosisbeta CateninCell ProliferationDisease Models, AnimalMaleMiceMice, Inbred C57BLMyocytes, CardiacOxidative StressRNA, MessengerSignal TransductionAdaptor Proteins, Signal Transducingbeta Cateninphosphoserine aminotransferaseRNA, MessengerSerineTransaminasesYap1 protein, mouseYAP-Signaling Proteinsapoptosiscardiac repaircardiomyocyte proliferationmRNA therapeuticsoxidative stressserine synthesis pathway

Identifiers

PMID40756345
PMCPMC12315692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.