Evidence map›Paper›PMID 40756343›Full record

ArticleTheranostics2025

Tumor Exosomal HIF2A Induce Peritumoral M2 Macrophages Accumulation to Facilitate Intestinal Invasion in Colorectal Cancer.

Dan Wang, Qingyang Lei, Li Yang, Yachang Huo, Weina Yu, Shasha Liu, Yangfei Duan, Shumin Feng, Zhen Li, Jinbo Liu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dan WangBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Qingyang LeiBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Li YangBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yachang HuoBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Weina YuBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Shasha LiuBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yangfei DuanBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Shumin FengBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Zhen LiDepartment of Anorectal Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Jinbo LiuDepartment of Anorectal Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Zhenqiang SunDepartment of Anorectal Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Weitang YuanDepartment of Anorectal Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Lihua LiuDepartment of Tumor Immunotherapy, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Bin ZhangDepartment of Medicine-Division of Hematology/Oncology, Feinberg School of Medicine Northwestern University, Chicago, Illinois 60611, USA.
Yi ZhangBiotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Basic Helix-Loop-Helix ProteinsColorectal NeoplasmsExosomesMacrophagesAnimalsCell Line, TumorChemokine CXCL12Disease Models, AnimalEndothelial PAS Domain-Containing Protein 1FemaleHumansMaleMiceMiddle AgedNeoplasm InvasivenessReceptors, CXCR4Basic Helix-Loop-Helix ProteinsChemokine CXCL12CXCL12 protein, humanEndothelial PAS Domain-Containing Protein 1Receptors, CXCR4CRCCXCL12/CXCR4exosomeintestinal invasionmacrophages

Identifiers

PMID40756343
PMCPMC12316027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.