Trial reportDrug design, development and therapy2025
Effect of Remimazolam versus Propofol on Hemodynamics in Elderly Hypertensive Patients Undergoing Gastroenteroscopy: A Multicenter, Randomized Controlled Clinical Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial.Annals of medicine · 2026Trial
- Remimazolam provides better hemodynamic stability than propofol in hypertensive surgical patients: a randomized single-blinded trial.Journal of anesthesia · 2026Trial
- Efficacy and safety of remimazolam besylate in patients receiving mechanical ventilation: A randomized phase Ⅱa trial.Journal of intensive medicine · 2026Article
- Age‑stratified median effective dose (ED₅₀) of remimazolam besylate for successful gastroscope insertion without body movement in geriatric patients.BMC anesthesiology · 2026Article
- Vasopressor requirements and hemodynamic stability during anesthesia using remimazolam and sevoflurane in patients undergoing minimally invasive aortic valve replacement surgery: a prospective randomized controlled study.Journal of thoracic disease · 2026Article
- Remimazolam Versus Propofol for General Anesthesia in Older Adults Undergoing Colon Cancer Surgery: A Systematic Review and Meta-Analysis of Comparative Studies.Pharmaceutics · 2026Review
- Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to compare the effects of remimazolam and propofol on hemodynamics in elderly hypertensive patients undergoing gastroenteroscopy. Methods: In this multicenter, single-blind, randomized clinical trial, 220 hypertensive patients (65-75 years) scheduled for gastroenteroscopy were randomly assigned to receive either remimazolam (group R, n=110; 0.3 mg/kg induction followed by 0.2-1 mg/kg/h maintenance) or propofol (group P, n=110; 1.5 mg/kg induction followed by 2-6 mg/kg/h maintenance), both combined with 0.1 μg/kg sufentanil. Flumazenil or placebo was administered for reversal. Hemodynamics were monitored via Continuous Non-Invasive Arterial Pressure (CNAP). The primary outcomes were hypotension incidence and hemodynamic parameters [mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), and systemic vascular resistance (SVR)]; secondary outcomes included the incidence of other adverse events and recovery time. Results: Group R exhibited significantly lower incidences of hypotension (72.7% vs 37.3%, Conclusion: Remimazolam provides superior hemodynamic stability and faster recovery compared to propofol in elderly hypertensive patients undergoing gastroenteroscopy, establishing it as a safer sedation option for this vulnerable patient population. Trial Number and Registry Url: Registration number, ChiCTR2400083757; https://www.chictr.org.cn/showproj.html?proj=214795.
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