ArticleDrug design, development and therapy2025
Efficacy and Long-Term Outcomes of Tacrolimus versus Cyclophosphamide and Mycophenolate Mofetil in the Management of Pediatric IgA Vasculitis Nephritis: A Cohort Study in Single-Center.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Telitacicept for childhood HSPN: A prospective self-controlled study.Clinical rheumatology · 2026Article
- Calcineurin Inhibitors: Current Role, Toxicity Management, and Future Frontiers in Immunosuppression.Molecular neurobiology · 2025Review
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9 authors.
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Abstract
Purpose: IgA vasculitis nephritis (IgAVN) is one of the most common secondary glomerulonephritis in children. Although guidelines have reached a consensus about the effectiveness of cyclophosphamide (CYC) in IgAVN, the recommendations regarding the use of tacrolimus (TAC) and mycophenolate mofetil (MMF) are still inconsistent. Studies have demonstrated that TAC is safe and effective in IgAVN. However, the impact of immunosuppressive agents on the long-term outcome remains ambiguous. Therefore, the objective of this study is to compare the effectiveness and long-term outcome of TAC, CYC, and MMF in combination with glucocorticoid in pediatric IgAVN. Patients and Methods: A retrospective analysis was conducted on children with grade II-V IgAVN by renal biopsy at Tongji Hospital from November 2011 to October 2021. The collected clinical, pathological, treatment and follow-up data were analyzed. Results: A total of 422 patients were eligible. Among them, 108 patients received glucocorticoid in combination with oral TAC, 143 with intravenous CYC, and 171 with oral MMF. The complete remission rate (CR) of TAC (25.9%/44.3%) was significantly higher than that of CYC (16.1%/36.4%) at 3 and 6 months. Additionally, mean absolute decrease in urine protein at 1, 3, and 6 months were significantly higher in TAC than that in CYC and MMF groups. Compared to CYC, TAC and MMF groups had significantly lower overall incidence of adverse events (60.2%, 65.7% vs 84.4%). Moreover, TAC and MMF group had a more favorable renal prognosis (grade A and B) and a significantly lower recurrence rate (17.9%, 23.9% vs 41.8%) than CYC. Conclusion: This study reveals that TAC can rapidly and effectively reduce proteinuria and achieve renal complete remission with fewer adverse effects. Moreover, TAC and MMF are more favourable for renal prognosis.
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