Diagnostic precision, safety, and patient experience of the freehand transperineal prostate biopsy technique under local anesthesia - A single-center experience.

Introduction: Transperineal access systems are commonly used to stabilize the biopsy needle with the ultrasound probe in local anesthetic transperineal biopsies (LATPs). However, these devices are expensive and nonreusable and restrict the access to some of the prostatic zones causing excessive probe movement and procedural pain. We aim to assess the pain tolerability, diagnostic value, and safety of the totally freehand LATP (tF-LATP) technique. Methods: Patients undergoing tF-LATP for suspected prostate cancer (PCa) from February 2024 to June 2024 were prospectively included. Data on the prostate-specific antigen (PSA) levels, prostate size, prostate multiparametric magnetic resonance imaging findings, cancer detection, need for immediate rebiopsy due to undersampling (with predefined criteria for immediate rebiopsy), tolerability, and complications were collected. Pain levels were assessed using the Visual Analog Scale (VAS) scores (scores 1-10) at rectal probe insertion and immediately postbiopsy. Results: Seventy-five patients ( Conclusions: The tF-LATP technique demonstrateed excellent safety, diagnostic efficacy, and satisfactory tolerability. With its cost-effectiveness and enhanced accessibility to all the prostatic lobes, clinicians are encouraged to integrate this technique more widely into clinical practice to maximize its advantages.