Evidence map›Paper›PMID 40756213›Full record

ReviewFrontiers in microbiology2025

Gut microbiota and viral respiratory infections: microbial alterations, immune modulation, and impact on disease severity: a narrative review.

Gaelle El-Khoury, Crystel Hajjar, Regina Geitani, Dolla Karam Sarkis, Marie-José Butel, Frédéric Barbut, Marianne Abifadel, Nathalie Kapel

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gaelle El-KhouryLaboratory of Microbiology, Faculty of Pharmacy, Saint Joseph University of Beirut, Beirut, Lebanon.
Crystel HajjarLaboratory of Microbiology, Faculty of Pharmacy, Saint Joseph University of Beirut, Beirut, Lebanon.
Regina GeitaniLaboratory of Microbiology, Faculty of Pharmacy, Saint Joseph University of Beirut, Beirut, Lebanon.
Dolla Karam SarkisLaboratory of Microbiology, Faculty of Pharmacy, Saint Joseph University of Beirut, Beirut, Lebanon.
Marie-José ButelINSERM S-1139, Université Paris Cité, Paris, France.
Frédéric BarbutINSERM S-1139, Université Paris Cité, Paris, France.
Marianne AbifadelLaboratory of Microbiology, Faculty of Pharmacy, Saint Joseph University of Beirut, Beirut, Lebanon.
Nathalie KapelINSERM S-1139, Université Paris Cité, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory viral infections are a major public health concern, accounting for millions of infections annually and contributing significantly to global morbidity and mortality. Influenza and respiratory syncytial virus (RSV) have long been recognized as critical pathogens, while the recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the COVID-19 pandemic. These viruses typically affect both the upper and lower respiratory tracts and can cause a broad spectrum of clinical manifestations, ranging from mild symptoms to severe respiratory failure and multi-organ dysfunction. Gastrointestinal symptoms are also frequently reported, suggesting a potential link between respiratory viruses and gut microbiota alterations. This connection highlights the role of the gut microbiota in disease pathophysiology. This narrative review summarizes current evidence on gut microbiota changes associated with SARS-CoV-2, influenza, and RSV infections. It further explores the microbiota's role in immune regulation and host homeostasis, and discusses the potential of microbiota-targeted strategies in the prevention and management of acute respiratory syndromes.

Indexed as

gut-lung axisgut microbiotainfluenzarespiratory virusesRSVSARS-CoV-2

Identifiers

PMID40756213
PMCPMC12313629

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.