ArticleFrontiers in microbiology2025
Related differences in fecal bacteria of Chinese northern pregnant women of different ages: associations with maternal clinical indicators and neonatal outcomes.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
The gut microbiota, a vital "microbial organ," influences digestion, immunity, and metabolism. Aging alters gut microbiota of pregnant women through metabolic and hormonal pathways, thereby impacting neonatal health. In this study conducted in northern China, we compared two groups: advanced maternal age (AMA, ≥35 years) and younger maternal age (YMA, 20-34 years), analyzing fecal bacteria and maternal metabolism via biomarker measurements and microbial sequencing. Results showed AMA had significantly higher serum levels of alkaline phosphatase (AKP), 25-hydroxyvitamin D [25(OH)D], and creatinine, while YMA exhibited higher Cu but lower Fe concentrations. Although the fecal bacteria of AMA participants showed greater diversity, the YMA group displayed a more stable bacterial composition, characterized by a higher abundance of beneficial bacteria (e.g.,
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