ArticleJournal of Indian Association of Pediatric Surgeons
Cystoscopic Local Application of Mitomycin-C following Internal Urethrotomy for Recurrent Short Urethral Strictures in Children: A Preliminary Experience.
Article in Journal of Indian Association of Pediatric Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Top ten surgical tricks-penile prosthesis with corporal fibrosis.International journal of impotence research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Urethral stricture (US) refers to the scarring process involving the corpus spongiosum (spongiofibrosis). Incidence in children is quite low as compared to adults, with anterior urethra (penile and bulbar) being the most common site. Iatrogenic and posttraumatic causes in the US are more frequent than the idiopathic, infective, and inflammatory causes. Either endoscopic internal urethrotomy (IU) (size < 2 cm US) or open reconstructive procedures (size > 2 cm US) are the main treatment options. However, additional therapy, such as the local application of Mitomycin C (MtMC), improves endoscopic success rates. In the current communication, we present a series of children with recurrent short US (<2 cm) following IU and even after reconstructive procedures, wherein we have tried to extend the benefit of MtMC application in combination with IU. Materials and Methods: Five consecutive children with recurrent short US (<2 cm) (following reconstructive procedures in traumatic US [ Results: The mean age of the patients was 8.4 ± 1.9 years. The mean pre-MtMC I-PSS score was 24 (severe). Post-MtMC application, the patients reported a symptomatically better urinary stream that was sustained beyond 4 weeks of catheter removal. When the urinary stream used to get thinned out, additional sittings of MtMC application were carried out. The time interval for re-intervention increased by 4-6 weeks, and on subsequent cystoscopic examinations at different time intervals, the urethral lumen was far much better (70%-80% improvement). The mean post-MtMC I-PSS score was 11 (moderate). During the early follow-up, the upper urinary tracts did not show any further deterioration as evidenced by DMSA scan done at 6 months. Uroflowmetry (plateau-shaped suggestive of static bladder outflow obstruction either anatomical or functional) and postvoid residual urine findings (~50% residual) were less encouraging. Conclusion: In terms of symptomatic relief, MtMC application has demonstrated its potential benefit on short follow-up for treating resistant US, as evidenced by a 40%-50% improvement in I-PSS score observed in all cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.