Evidence map›Paper›PMID 40756032›Full record

ArticleFrontiers in cellular and infection microbiology2025

Imidazolium salts carrying two positive charges: design, synthesis, characterization, molecular docking, antibacterial and enzyme inhibitory activities.

Ilter Demirhan, Adem Necip, Erkan Oner, Nalin Gumuscu, Ozlem Demirci, Yetkin Gok, Nebiye Yentur Doni, Mesut Işık, Mithun Rudrapal, Johra Khan and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilter DemirhanDepartment of Electronic-Otomation, Biomedical Device Technology Program, Vocational School of Health Services, Harran University, Sanlıurfa, Türkiye.
Adem NecipDepartment of Pharmacy Services, Vocational School of Health Services, Harran University, Sanlıurfa, Türkiye.
Erkan OnerDepartment of Biochemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman, Türkiye.
Nalin GumuscuDepartment of Dental Services, Vocational School of Health Services, Harran University, Sanlıurfa, Türkiye.
Ozlem DemirciDepartment of Chemistry, Faculty of Arts and Science, Inönü University, Malatya, Türkiye.
Yetkin GokDepartment of Chemistry, Faculty of Arts and Science, Inönü University, Malatya, Türkiye.
Nebiye Yentur DoniDepartment of Medical Microbiology, Faculty of Medicine, Harran University, Salnlıurfa, Türkiye.
Mesut IşıkDepartment of Bioengineering, Faculty of Engineering, Bilecik Şeyh Edebali University, Bilecik, Türkiye.
Mithun RudrapalDepartment of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan's Foundation for Science, Technology and Research, Guntur, India.
Johra KhanDepartment of Medical Laboratory Sciences, College of Applied Medical Laboratory Sciences, Majmaah University, Al Majma'ah, Saudi Arabia.
Randa Mohammad IbrahimDepartment of Medical Laboratory Sciences, College of Applied Medical Laboratory Sciences, Majmaah University, Al Majma'ah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The discovery of alternative drugs has gained importance due to the many side effects of these drugs used for treatment. Methods: Herein, the synthesis of a series of unsymmetrical imidazolium salts containing 4-acetylphenyl/4-formylphenyl and bioactive heterocyclic groups such as morpholine, piperidine, pyrrole or pyridine was reported. 4-(1- Results: The inhibitory effect against AChE of the series compounds was evaluated as Conclusions: The results suggested that the synthesized compounds showed the potential to be antimicrobial and acetylcholinesterase inhibitors.

Indexed as

Anti-Bacterial AgentsCholinesterase InhibitorsEnzyme InhibitorsImidazolesAcetylcholinesteraseBacteriaDrug DesignMicrobial Sensitivity TestsMolecular Docking SimulationSaltsStructure-Activity RelationshipAcetylcholinesteraseAnti-Bacterial AgentsCholinesterase InhibitorsEnzyme InhibitorsImidazolesSaltsacetylcholinesteraseanti-Alzheimerantimicrobialimidazolium saltN-heterocyclic carbene

Identifiers

PMID40756032
PMCPMC12313567

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.