Evidence map›Paper›PMID 40756024›Full record

ArticlePCN reports : psychiatry and clinical neurosciences2025

Increased use of attention-deficit/hyperactivity disorder drugs among children and adolescents with suicidal ideation: A real-world registry study in Japan.

Noa Tsujii, Hiroaki Kihara, Akiko Hiraiwa, Haruko Tachibana, Maya Ueno, Asami Takasaki, Chikako Igarashi, Naohito Kaneko, Kotoe Itagaki, Keita Yamamoto and 4 more

Abstract read
In one paragraph

Article in PCN reports : psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Noa TsujiiDepartment of Child Mental Health and Development Toyama University Hospital Toyama Toyama Japan.ORCID https://orcid.org/0000-0003-3434-6280
Hiroaki KiharaDepartment of Neuropsychiatry Kanazawa Medical University Uchinada Ishikawa Japan.
Akiko HiraiwaDepartment of Child Mental Health and Development Toyama University Hospital Toyama Toyama Japan.
Haruko TachibanaDepartment of Neuropsychiatry University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Toyama Toyama Japan.
Maya UenoDepartment of Psychiatry Tokyo Metropolitan Toshima Hospital Tokyo Japan.
Asami TakasakiDepartment of Pediatrics, Faculty of Medicine University of Toyama Toyama Toyama Japan.
Chikako IgarashiDepartment of Neuropsychiatry University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Toyama Toyama Japan.
Naohito KanekoDepartment of Neuropsychiatry University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Toyama Toyama Japan.
Kotoe ItagakiDepartment of Clinical Psychology, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Japan.
Keita YamamotoDepartment of Social Work, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Japan.
Kumi InazakiDepartment of Child and Adolescent Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba Japan.
Yuki HakoshimaDepartment of Child and Adolescent Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba Japan.
Yuki MizumotoDepartment of Child and Adolescent Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba Japan.
Masahide UsamiDepartment of Child and Adolescent Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Suicidality remains a significant clinical concern for individuals with attention-deficit/hyperactivity disorder (ADHD) receiving treatment with ADHD medications, especially children and adolescents. This retrospective cohort study examined the association between suicidal ideation and the initiation of ADHD medications among children and adolescents with ADHD. Methods: Using children's mental health registry data from the National Center for Global Health and Medicine, this study included 431 patients aged 5-15 years diagnosed with ADHD and recorded their use of ADHD medications up to 5 years after the diagnosis. The baseline assessment of suicidal ideation was based on Item 10 of the Depression Self-Rating Scale for Children. The primary outcome was the incidence of the initiation of ADHD medications within 3 months after the diagnosis of ADHD. Results: At baseline assessment, 143 (33.2%) of 431 patients with ADHD had suicidal ideation. Multivariable logistic regression models revealed that suicidal ideation, older age, and more severe ADHD symptoms were all associated with the initiation of ADHD medications within 3 months after the diagnosis. Conclusion: These results suggest that among children and adolescents with ADHD, caution and vigilant monitoring for suicidal ideation are crucial before initiating ADHD medications; follow-up is necessary according to the severity of their condition.

Indexed as

attention‐deficit/hyperactivity disorderpsychopharmacologysuicidal ideationsuicidality

Identifiers

PMID40756024
PMCPMC12313820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.