ArticleClinical kidney journal2025
Longitudinal patterns of fluid overload, blood volume and vascular refilling: a prospective study in patients on maintenance hemodialysis.
Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Fluid overload modifies ambulatory blood pressure and pulse wave characteristics in hemodialysis patients undergoing targeted fluid management.Clinical kidney journal · 2026Article
- Is Anything Gained From Estimating Blood Volume in Hemodialysis From Extracellular Volume Divided by a Constant Factor?Hemodialysis international. International Symposium on Home Hemodialysis · 2026Article
- Effects of Pre-Dialysis Fluid Overload, Intradialytic Relative Blood Volume Levels, and Cumulative Ultrafiltration Volume on Pulse Wave-Derived Features during Hemodialysis: Results from a Longitudinal Cohort Study.Kidney & blood pressure research · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Patients on maintenance hemodialysis accumulate excess fluid between treatments. Intradialytic removal of fluid via ultrafiltration is partly compensated by vascular refilling from the interstitial space. Associations between whole-body fluid status and blood volume were previously investigated on the population level. The aim of this observational cohort study was to assess longitudinal changes in fluid compartment volumes on an intra-patient level. Methodology: Pre-dialysis bioimpedance spectroscopy measurements and absolute blood volume estimations were conducted in maintenance hemodialysis patients during 14 consecutive dialysis treatments over 5 weeks. Blood volume was determined using the dialysate bolus method. Longitudinal changes were evaluated using linear mixed models. Correlations were analyzed with repeated measures correlation coefficients ([Formula: see text]). Results: Twenty-five patients were included in the final analysis [88% male, median (quartile 1, quartile 3) age and dialysis vintage of 66.0 years (48.0, 74.0) and 23.5 months (13.5, 34.5), respectively]. Pre-dialysis fluid overload significantly decreased from the first to the third treatment within the week ( Conclusions: The observed lack of intra-patient correlations between pre-dialysis fluid overload and blood volume suggests that excess fluid may not necessarily accumulate proportionally in the interstitial and intravascular space, thus challenging previous assumptions regarding within-week changes in fluid compartments.
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