Evidence map›Paper›PMID 40755777›Full record

ArticleFrontiers in immunology2025

Case Report: Cadonilimab plus anlotinib with radiotherapy for lung adenocarcinoma with pancreatic metastasis in later-line therapy.

Jianquan Yang, Zixin Li, Xuezhou Pang, Yakun Zhang, Beilei Zeng, Yan Gui, Daiyuan Ma

Abstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianquan YangDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Zixin LiDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Xuezhou PangDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Yakun ZhangDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Beilei ZengDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Yan GuiDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Daiyuan MaDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with advanced lung adenocarcinoma lacking driver gene mutations face the clinical dilemma of limited treatment options and poor prognosis in later-line therapy. Although immune checkpoint inhibitors (ICIs) combined with anti-angiogenic agents offer a promising approach, the optimal treatment strategy remains to be explored. In this report, we present a case of advanced lung adenocarcinoma with pancreatic metastasis treated with cadonilimab plus anlotinib and radiotherapy to the pancreatic lesion, resulting in 11 months of progression-free survival (PFS) and only minor side effects. This outcome suggests the potential value of cadonilimab and anlotinib in later-line therapy for advanced lung adenocarcinoma and provides a possible new treatment option for such patients.

Indexed as

Adenocarcinoma of LungAntineoplastic Combined Chemotherapy ProtocolsLung NeoplasmsPancreatic NeoplasmsAntibodies, Monoclonal, HumanizedHumansIndolesQuinolinesTreatment OutcomeanlotinibAntibodies, Monoclonal, HumanizedIndolesQuinolinesanlotinibcadonilimablung adenocarcinomapancreatic metastasisradiotherapy

Identifiers

PMID40755777
PMCPMC12313661

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.