ReviewCureus2025
Obesity Epidemic and Its Impact on Female Fertility: Current Understanding and Future Directions.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Immunometabolic Dysregulation in Female Obesity: Mechanistic Links to Ovarian Dysfunction, Implantation Failure, and Preeclampsia.Biomedicines · 2026Review
- BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF.International journal of molecular sciences · 2026Review
- Targeting metabolism to protect fertility and healthy pregnancy with SGLT2 inhibitors and GLP-1RAs.Current opinion in physiology · 2026Article
- Therapeutic Potential of Anti-Obesity Drugs in Obesity-Associated Female Reproductive Dysfunction: Translating Mechanistic Evidence into Personalized Clinical Strategies.Medicina (Kaunas, Lithuania) · 2026Review
- Genistein in polycystic ovary syndrome: mechanisms, preclinical evidence, and translational potential.Frontiers in global women's health · 2026Review
- BMI and idiopathic infertility drive polarized redox phenotypes in human follicular fluid.Frontiers in endocrinology · 2026Article
- Development and external validation of a metabolic and lipid-based model for predicting subsequent pregnancy in women with endometriosis.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a global epidemic with profound implications for fertility in women of reproductive age. This review summarizes how obesity affects fertility by disrupting the hypothalamic-pituitary-ovarian (HPO) axis, affecting oocyte quality and reserve, and compromising endometrial receptivity. The combination of these disruptions leads to reduced fertility rates, decreased success with assisted reproductive technologies (ARTs), and increased risk for adverse pregnancy outcomes. This review also examines the impact of interventions for weight loss, including lifestyle modifications, medications, and surgery, on female fertility. Overall, these interventions show promise in anovulatory cycles; however, their impact on live birth rates (LBRs) remains variable. Newer therapies, such as glucagon-like peptide 1 receptor agonists (GLP-1 RAs), have expanded the armamentarium of options for obesity management. Emerging data suggest potential roles for GLP-1 RAs in ovarian and endometrial function, suggesting broader applications in reproductive health. Given the complexity of obesity's impact on reproduction, a multidisciplinary approach incorporating lifestyle modification, pharmacotherapy, and, if necessary, surgery offers the most significant potential to optimize reproductive success.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.