Evidence map›Paper›PMID 40755527›Full record

ArticleToxicology research2025

Puerarin alleviates high glucose-induced lens epithelial cell damage by activating the Nrf2 Signaling pathway to inhibit oxidative stress.

Juan Xia, Mingli Zhou, Yuandong Ma, Song Zhang, Shanshan Tang, Jie Zhang

Abstract read
In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juan XiaDepartment of Endocrinology, Yizheng Hospital of Chinese Medicine, 899 Yanshanhe East Road, Yizheng, Jiangsu 211400, China.
Mingli ZhouDepartment of Preventive Medicine, Yizheng Clinical School, Jiangsu Health Vocational College, 899 Yanshanhe East Road, Yizheng, Jiangsu 211400, China.
Yuandong MaDepartment of Ophtalmology, Yizheng Hospital of Chinese Medicine, 899 Yanshanhe East Road, Yizheng, Jiangsu 211400, China.
Song ZhangDepartment of Endocrinology, Yizheng Hospital of Chinese Medicine, 899 Yanshanhe East Road, Yizheng, Jiangsu 211400, China.
Shanshan TangDepartment of Ophtalmology, Yizheng Hospital of Chinese Medicine, 899 Yanshanhe East Road, Yizheng, Jiangsu 211400, China.
Jie ZhangDepartment of Ophtalmology, Yizheng Clinical School, Jiangsu Health Vocational College, 899 Yanshanhe East Road, Yizheng, Jiangsu 211400, China.ORCID https://orcid.org/0000-0002-3526-8168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated Puerarin's protective effects and mechanisms against high glucose (HG)-induced damage in human lens epithelial cells (HLECs), which are relevant to diabetic complications. Using an HG-exposed HLEC model, varying doses of Puerarin (10 μM, 20 μM, 50 μM) were tested. While non-toxic to normal HLECs, both 20 μM and 50 μM Puerarin significantly and dose-dependently restored cell viability reduced by HG (

Indexed as

high glucoselens epithelial cell damageNrf2 signaling pathwayoxidative stressPuerarin

Identifiers

PMID40755527
PMCPMC12315543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.