ArticleFrontiers in surgery2025
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a rare case report and review of the literature.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UC-OGCP) is an exceedingly rare malignant tumour that accounts for less than 1% of all pancreatic nonendocrine neoplasms. Case presentation: We present a case of UC-OGCP in a 46-year-old male patient who was referred to our hospital after the incidental identification of a cystic tumour in the pancreas. Computed tomography (CT) revealed a 1.4 × 1.4 × 1.6-cm mass in the pancreatic head. Surgical resection was performed because it was difficult to determine the degree of malignancy of the tumour through clinical assessment. Intraoperative frozen-section pathology confirmed that the tumour was a malignant neoplasm. Pancreaticoduodenectomy was subsequently conducted. Histopathological studies confirmed the diagnosis of UC-OGCP. Conclusion: The clinical symptoms of UC-OGCP are nonspecific, and there are no distinct serological markers. Diagnosis relies primarily on endoscopic biopsy or postoperative pathology. We report this case of UC-OGCP and provide a literature review on the clinicopathological features, differential diagnosis, treatment, and prognosis of UC-OGCP, aiming to improve the understanding of this disease.
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