Evidence map›Paper›PMID 40755445›Full record

ArticleLab on a chip2025

Utility of an

Adriana Martinez Ledo, Gabriela Misiewicz, Thomas Dimke, William R Tschantz, Jillian Handel, Ryan Pelis, Gerard Bruin, Karoline Bechtold-Peters, Manuel Sanchez-Felix, Sujal Deshmukh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adriana Martinez LedoPharmacokinetic Sciences, Novartis Biomedical Research, Cambridge, MA 02139, USA. adriana.martinez_ledo@novartis.com.ORCID 0000-0002-5130-259X
Gabriela MisiewiczPharmacokinetic Sciences, Novartis Biomedical Research, Cambridge, MA 02139, USA. adriana.martinez_ledo@novartis.com.
Thomas DimkePharmacokinetic Sciences, Novartis Biomedical Research, CH-4056 Basel, Switzerland.ORCID 0000-0002-4163-8794
William R TschantzBiologics Research Center, Novartis Biomedical Research, Cambridge, MA 02139, USA.
Jillian HandelIntern at Novartis Biomedical Research, Summer of Science Program, USA.ORCID 0000-0002-6870-5619
Ryan PelisPharmacokinetic Sciences, Novartis Biomedical Research, Cambridge, MA 02139, USA. adriana.martinez_ledo@novartis.com.
Gerard BruinPharmacokinetic Sciences, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Karoline Bechtold-PetersTechnical Research and Development, Novartis Pharma AG, 4002 Basel, Switzerland.
Manuel Sanchez-FelixNovartis Biomedical Research, Cambridge, MA 02139, USA.
Sujal DeshmukhPharmacokinetic Sciences, Novartis Biomedical Research, Cambridge, MA 02139, USA. adriana.martinez_ledo@novartis.com.
Seunggyu KimDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-0661-4583
Maria ProestakiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Roger D KammDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-7232-304X

Funding

The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
NIBIB NIH HHS P41 EB031772
6 · The paper itself

Abstract

The lymphatic vasculature plays a key role in the subcutaneous absorption of macromolecules (>16 kDa). Recent trends toward subcutaneous delivery of macromolecular therapeutics have brought awareness to the need for preclinical estimation of subcutaneous bioavailability prior to first-in-human studies.

Indexed as

Antibodies, MonoclonalLab-On-A-Chip DevicesLymphatic VesselsModels, BiologicalAnimalsHumansAntibodies, Monoclonal

Identifiers

PMID40755445
PMCPMC12771666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.