Evidence map›Paper›PMID 40755425›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Tailoring Regioselectivity-Controlled UDP-Glycosyltransferase for Bidirectional Glycosylation of Tyrosol via Free Energy-Driven Pocket Reshaping and Tunnel Engineering.

Ziyu Zhang, Jingyi Chen, Zuozhi Liang, Wenming Shao, Zhen Gao, Bin Wu, Bingfang He, Gerhard Schenk

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziyu ZhangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhunan Road, Nanjing, 211816, China.
Jingyi ChenCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhunan Road, Nanjing, 211816, China.
Zuozhi LiangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhunan Road, Nanjing, 211816, China.
Wenming ShaoCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhunan Road, Nanjing, 211816, China.
Zhen GaoCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhunan Road, Nanjing, 211816, China.
Bin WuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhunan Road, Nanjing, 211816, China.ORCID https://orcid.org/0000-0003-3785-1266
Bingfang HeSchool of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhunan Road, Nanjing, 211816, China.
Gerhard SchenkSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Funding

Basic Research Program of Jiangsu Province BK20233003National Natural Science Foundation of China 22478189
6 · The paper itself

Abstract

UDP-glycosyltransferases (UGTs) are pivotal biocatalysts for synthesizing pharmaceutically valuable active components; however, their application is frequently constrained by poor regioselectivity and suboptimal catalytic efficiency. In this study, a tailored, free energy-driven, substrate-binding pocket reshaping strategy is implemented to pinpoint the specific residues in UGT

Indexed as

GlycosyltransferasesPhenylethyl AlcoholGlucosidesGlycosylationPhenolsProtein EngineeringSubstrate Specificity4-hydroxyphenylethanolGlucosidesGlycosyltransferasesPhenolsPhenylethyl Alcoholrhodiolosidefree‐energy landscapeicariside D2protein engineeringsalidrosideUDP‐Glycosyltransferase

Identifiers

PMID40755425
PMCPMC12561194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.