ReviewEndocrinology2025
Emerging Mechanisms of Therapy Resistance in Metastatic ER+ Breast Cancer.
Review in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Evolving First-Line Endocrine Therapy in HR+/HER2- Metastatic Breast Cancer: CDK4/6 Inhibition, Biomarker-Guided Strategies and Emerging Therapeutic Paradigms.Current oncology (Toronto, Ont.) · 2026Review
- Therapy as a State-Generator: Dynamic Phenotypic Landscapes and Adaptive Stress Circuits in Chemotherapy Resistance of Breast Cancer.Antioxidants (Basel, Switzerland) · 2026Review
- Decoding Breast Cancer: Emerging Molecular Biomarkers and Novel Therapeutic Targets for Precision Medicine.International journal of molecular sciences · 2025Review
- Metastatic patterns and survival outcomes across molecular subtypes in a large cohort of breast cancer patients from the Shiraz breast cancer registry.Discover oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Breast cancer is the most frequently diagnosed cancer in women, with more than 316 000 new cases expected to be diagnosed in 2025. Nearly 80% of new breast cancer cases will be estrogen receptor-positive (ER+). While ER+ breast cancer has a high 5-year survival rate, patients are at risk of developing late recurrence and metastasis for 10 to 20 years after initial diagnosis. Late recurrence and metastasis are associated with therapy resistance and disease progression. Understanding the molecular mechanisms that drive therapy resistance and disease progression is essential for the development of therapies that will prevent and treat advanced ER+ breast cancer. This review will focus on mechanisms of therapy resistance associated with standard treatments for advanced ER+ breast cancer, including CDK4/6 inhibitors and PI3K/AKT/mTOR pathway inhibitors. Additionally, we will highlight how therapy resistance enriches for breast cancer stem-like populations and how targeting this population of cells may be advantageous for preventing breast cancer progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.