Evidence map›Paper›PMID 40755361›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Dual-Wavelength Responsive Hydrogel Glue with Visible-Light Bonding and UV-Triggered Debonding via Ortho-Nitrobenzyl Cleavage.

Huaming Wang, Xianyan Shen, Changling Du, Xian-You Liu, Anyu Yang, Yanni Cao, Aijie Han, Qihan Liu, Jennifer Laaser, Wei Zhang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huaming WangDepartment of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID https://orcid.org/0000-0003-4249-6182
Xianyan ShenDepartment of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Changling DuDepartment of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Xian-You LiuDepartment of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Anyu YangDepartment of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Yanni CaoDepartment of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Aijie HanDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Qihan LiuDepartment of Mechanical Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Jennifer LaaserDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.ORCID https://orcid.org/0000-0002-0551-9659
Wei ZhangDepartment of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID https://orcid.org/0000-0002-9321-6411

Funding

Light triggered materials for on-demand local anesthesia and tissue adhesive dissolutionR00GM141269 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Wei Zhang · 2024 to 2026
$747k
Foundation for the National Institutes of Health R00GM141269National Science Foundation 2337592NIGMS NIH HHS R00 GM141269
6 · The paper itself

Abstract

Removable adhesives with controllable bonding and debonding capabilities are essential for biomedical devices, temporary fixation, and recyclable materials. Here, a dual-wavelength hydrogel glue is presented that integrates visible-light polymerization (470 nm) for strong adhesion and UV-induced degradation (365 nm) for rapid debonding. The system leverages camphorquinone as a visible-light photoinitiator and ortho-nitrobenzyl poly(ethylene glycol) dimethacrylate (ONB-PEGDMA) as a UV-cleavable crosslinker, ensuring independent control over adhesion and detachment with orthogonal polymerization and degradation. The degradation rate of ONB-PEGDMA increases proportionally with light intensity, providing precise control over cleavage kinetics, with first-order rate constants of 0.155, 0.278, and 0.669 min

Indexed as

decrosslinkinghydrogelortho‐nitrobenzylphoto‐responsiveremovable glue

Identifiers

PMID40755361
PMCPMC12561338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.